Evidence map›Paper›PMID 35424209›Full record

ArticleRSC advances2021

pH and redox dual-sensitive drug delivery system constructed based on fluorescent carbon dots.

Boye Zhang, Qianqian Duan, Yi Li, Jianming Wang, Wendong Zhang, Shengbo Sang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 4 countries.

Boye ZhangMicroNano System Research Center, College of Information and Computer, Key Laboratory of Advanced Transducers and Intelligent Control System of the Ministry of Education and Shanxi Province, Taiyuan University of Technology Taiyuan 030024 China wwhwls@163.com sunboa-sang@tyut.edu.cn.
Qianqian DuanMicroNano System Research Center, College of Information and Computer, Key Laboratory of Advanced Transducers and Intelligent Control System of the Ministry of Education and Shanxi Province, Taiyuan University of Technology Taiyuan 030024 China wwhwls@163.com sunboa-sang@tyut.edu.cn.
Yi LiTheranostic Macromolecules Research Center, School of Chemical Engineering, Sungkyunkwan University Suwon 16419 Republic of Korea.
Jianming WangWound Repair Department, General Hospital of TISCO Taiyuan 030003 China.
Wendong ZhangMicroNano System Research Center, College of Information and Computer, Key Laboratory of Advanced Transducers and Intelligent Control System of the Ministry of Education and Shanxi Province, Taiyuan University of Technology Taiyuan 030024 China wwhwls@163.com sunboa-sang@tyut.edu.cn.
Shengbo SangMicroNano System Research Center, College of Information and Computer, Key Laboratory of Advanced Transducers and Intelligent Control System of the Ministry of Education and Shanxi Province, Taiyuan University of Technology Taiyuan 030024 China wwhwls@163.com sunboa-sang@tyut.edu.cn.ORCID https://orcid.org/0000-0003-3011-7632
Taiyuan University of Technology · CNAltair Engineering (United States) · USGovernment of the Republic of Korea · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, a pH and redox dual-responsive drug delivery system (CDs-Pt(iv)-PEG) was developed based on fluorescence carbon dots (CDs). In this system, cisplatin(iv) prodrug (Pt(iv)) was selected as a model drug to reduce toxic side effects. The aldehyde-functionalized monomethoxy polyethylene glycol (mPEG-CHO) was conjugated to CDs-Pt(iv) to form pH sensitive benzoic imine bond. Owing to the slightly acidic tumor extracellular microenvironment (pH 6.8), the benzoic imine bond was then hydrolyzed, leading to charge reversal and decrease in the hydration radius of the drug-carrying, which facilitated

Identifiers

PMID35424209
PMCPMC8693813
OpenAlexW3120177602

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.