ReviewRSC advances2021
Metal-free multicomponent approach for the synthesis of propargylamine: a review.
Review in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 56 citations in OpenAlex.
- Magnetically recoverable catalysts for efficient multicomponent synthesis of organosulfur compounds.RSC advances · 2025Review
- Formaldehyde surrogates in multicomponent reactions.Beilstein journal of organic chemistry · 2025Review
- Article
- Dendrimer templated ionic liquid nanomagnetic for efficient coupling reactions.Scientific reports · 2024Article
- eFluorination for the Rapid Synthesis of Carbamoyl Fluorides from Oxamic Acids.Organic letters · 2024Article
- Synthesis of tricarbonylated propargylamine and conversion to 2,5-disubstituted oxazole-4-carboxylates.Beilstein journal of organic chemistry · 2024Article
- Magnetic nanoparticles modified with a copper(i) complex as a novel and efficient reusable catalyst for ARSC advances · 2023Article
- Highly Selective Cyclization and Isomerization of Propargylamines to Access Functionalized Quinolines and 1-Azadienes.Molecules (Basel, Switzerland) · 2023Article
- In Melting Points We Trust: A Review on the Misguiding Characterization of Multicomponent Reactions Adducts and Intermediates.Molecules (Basel, Switzerland) · 2022Review
- Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones.Molecules (Basel, Switzerland) · 2022Article
- Catalytic Approaches to Multicomponent Reactions: A Critical Review and Perspectives on the Roles of Catalysis.Molecules (Basel, Switzerland) · 2021Review
- Solvent-free synthesis of propargylamines: an overview.RSC advances · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Propargylamines are important classes of alkyne coupled amine compounds used in heterocyclic chemistry and pharmaceuticals chemistry and have a large impact as a pharmacophore used in medicinal chemistry. One of the straightforward approaches for the synthesis of this class of compound is A3 coupling, a three-component coupling reaction among aldehyde, alkyne (terminal acetylene) and amine. However, there are many methods other than conventional three component alkyne-aldehyde-amine (A3) coupling which have also been reported for the synthesis of propargylamine. Most of these methods are based on the metal catalyzed activation of terminal alkyne. From the perspective of green and sustainable chemistry, the scientific community should necessarily focus on metal-free techniques which can access a variety of propargylamines. There are only a few reports found in the literature where propargylamines were successfully synthesized under metal-free conditions. This present review article neatly and precisely encompasses the comprehensive study of metal-free protocols in propargylamine synthesis putting forth their mechanisms and other aspects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.