ArticleRSC advances2020
Traceless solid-phase synthesis and β-turn propensity of 1,3-thiazole-based peptidomimetics.
Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Revisiting Pyrimidine-Embedded Molecular Frameworks to Probe the Unexplored Chemical Space for Protein-Protein Interactions.Accounts of chemical research · 2024Article
- Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies.Pharmaceuticals (Basel, Switzerland) · 2021Review
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Authors and funding
2 authors.
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Abstract
The design and solid-phase synthesis of 1,3-thiazole-based peptidomimetic molecules is described. The solid-phase synthesis was based on the utilization of a traceless linker strategy. The synthesis starts from the conversion of chloromethyl polystyrene resin to the resin with a sulfur linker unit. The key intermediate 4-amino-thiazole-5-carboxylic acid resin is prepared in three steps from Merrifield resin. The amide coupling proceeded at the C4 and C5 positions
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