ArticleRSC advances2021
Total synthesis of landomycins Q and R and related core structures for exploration of the cytotoxicity and antibacterial properties.
Article in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Stereodivergent total synthesis of C5/C6-oxygenated angucyclines: stereochemical reassignment and antitumor activities.Chemical science · 2026Article
- Total Synthesis of Allocyclinone A via Late-Stage Halogen Swapping.Angewandte Chemie (International ed. in English) · 2026Article
- Rapid spectrophotometric detection for optimized production of landomycins and characterization of their therapeutic potential.Biotechnology and bioengineering · 2024Article
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Authors and funding
10 authors.
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Abstract
Herein, we report the total synthesis of landomycins Q and R as well as the aglycone core, namely anhydrolandomycinone and a related core analogue. The synthesis features an acetate-assisted arylation method for construction of the hindered B-ring in the core component and a one-pot aromatization-deiodination-denbenzylation procedure to streamline the global functional and protecting group manuipulation. Subsequent cytotoxicity and antibacterial studies revealed that the landomycin R is a potential antibacterial agent against methicillin-resistant
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