ArticleRSC advances2021
Fabrication and characterization of 3D printable nanocellulose-based hydrogels for tissue engineering.
Article in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Role of cellulose and its derivatives for 3D printing of bone tissue scaffolds.Frontiers in bioengineering and biotechnology · 2026Review
- 3D printed scaffolds of biosilica and spongin from marine sponges: analysis of genotoxicity and cytotoxicity for bone tissue repair.Bioprocess and biosystems engineering · 2024Article
- The Development of a Bacterial Nanocellulose/Cationic Starch Hydrogel for the Production of Sustainable 3D-Printed Packaging Foils.Polymers · 2024Article
- Nanoengineered injectable hydrogels derived from layered double hydroxides and alginate for sustained release of protein therapeutics in tissue engineering applications.Journal of nanobiotechnology · 2023Article
- Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine.Bioactive materials · 2023Review
- Cellulose Nanocrystal (CNC) Gels: A Review.Gels (Basel, Switzerland) · 2023Review
- Nanocellulose: Recent Advances Toward Biomedical Applications.Small science · 2023Article
- Comparison of the potential for bioprinting of different 3D printing technologies.International journal of bioprinting · 2023Article
- Application of 3D-bioprinted nanocellulose and cellulose derivative-based bio-inks in bone and cartilage tissue engineering.International journal of bioprinting · 2023Article
- Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications.Bioactive materials · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellulose nanocrystal (CNC)-based hydrogels are considered attractive biomaterials for tissue engineering due to their excellent physicochemical properties. Hydrogels of alginate and gelatin were prepared with or without CNCs and printed using a CELLINK® BIOX 3D bio-printer. The 3D-printed scaffolds were characterized by Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, transmission electron microscopy (TEM), and scanning electron microscopy (SEM). Improved mechanical strength was observed in the composite scaffolds compared to the pure polymer scaffolds. Fabricated scaffolds exhibited superior swelling potential; this property is profoundly affected by the CNC content of hydrogels. Biocompatibility of the fabricated scaffolds was monitored in the presence of human bone marrow-derived mesenchymal stem cells (hBMSCs) using the WST-1 assay. Notably, better cell viability was observed in the composite scaffolds than in the control, indicating improved biocompatibility of composites. Cells were healthy and adhered appropriately to the surface of the scaffolds. Mineralization potential of the prepared scaffolds was evaluated by the alizarin red S (ARS) staining technique in the presence of hBMSCs after 7 and 14 days of treatment. Enhanced mineral deposition was observed in the composite scaffolds compared to the control, indicating superior composite mineralization potential. Upregulation of osteogenic-associated genes was observed in the scaffold-treated groups relative to the control, showing superior scaffold osteogenic potential. These results demonstrate that 3D-printed scaffolds are potential candidates for bone tissue engineering applications.
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Registered trials
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