ArticleRSC advances2021
Fullerene translocation through peroxidized lipid membranes.
Article in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Bolus MPTP Injection in Aged Mice to Mimic Parkinson Disease: Effects of Low-Dose Antioxidant Treatment with Fullerene (CBiomedicines · 2025Article
- Insight into the interactions of fullerenes with biological membranes through molecular dynamics simulations.Advances in physics: X · 2024Article
- Coarse-grained modeling of polystyrene-modified CNTs and their interactions with lipid bilayers.Biophysical journal · 2023Article
- Polystyrene-modified carbon nanotubes: Promising carriers in targeted drug delivery.Biophysical journal · 2022Article
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Authors and funding
2 authors.
Funding
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Abstract
Recent cytotoxicity research suggests that fullerenes can enter the cell and cross the blood-brain barrier. However, the underlying toxicity mechanism behind the penetration of fullerenes through biological membranes is still not well understood. Here we perform coarse-grained molecular dynamics simulations to investigate the interactions of fullerenes and their polar derivatives (Janus) with model regular and peroxidized bilayers. We show that the translocation of fullerenes and their residence time in bulk water vary depending on the bilayer's peroxidation degree and fullerene polarity. The distribution of fullerenes inside the bilayer is mainly determined by the peroxidation degree and the saturation level of lipid acyl chains. The transport of pristine fullerenes through bilayers occurs at nano timescale while the complete diffusion may not be achieved for Janus fullerenes in micro timescale. As for the toxic response of fullerenes in terms of membrane damage, no mechanical disruption of model bilayers is observed throughout the studied simulation times.
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Registered trials
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