ArticleAmerican journal of translational research2022
Combined detection of anticardiolipin and anti-β2-glycoprotein 1 antibodies may predict pregnancy outcome.
Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Even low levels of anticardiolipin antibodies are associated with pregnancy-related complications: A monocentric cohort study.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Evaluation of platelet parameters, coagulation markers, antiphospholipid syndrome, and thyroid function in palestinian women with recurrent pregnancy loss.BMC pregnancy and childbirth · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antiphospholipid syndrome (APS) is a typical non-inflammatory autoimmune disease that is common in young women. It is characterized by the presence of the anti-cardiolipin antibody (ACA) and anti-β2 glycoprotein 1 (anti-β2-GP1) antibody and is associated with a high risk of arteriovenous thrombosis. We measured the expression of ACA and anti-β2-GP1 antibodies in the serum of pregnant women early in their pregnancy, and analyzed the pregnancy outcome of the primigravidas who were positive for both the antibodies, so as to evaluate the efficacy of the combined determination in predicting pregnancy outcome. A total of 102 pregnant women who visited the Hebei General Hospital from January 2014 to December 2017 were enrolled in the study. The serum levels of ACA and anti-β2-GP1 antibodies were determined in all the enrolled pregnant women using the enzyme-linked immunosorbent assay (ELISA) method and the correlation between positive ACA/anti-β2-GP1 antibody and the adverse pregnancy outcomes was analyzed. Meanwhile, the difference in the pregnancy outcomes between patients who were positive for ACA only, for anti-β2-GP1 only and for both of the two antibodies was also investigated. The incidence of adverse pregnancy outcomes of pregnant women who were positive for both the ACA and the anti-β2-GP1 antibodies (48.87%) was higher than that of those positive for ACA only (28.67%) and those positive for anti-β2-GP1 only (36.66%). The positive predictive value (PPV), negative predictive value (NPV), sensitivity and specificity of the combined determination of the two predictors was 81.75%, 95.84%, 88.37% and 95.92%, respectively. The combined determination of ACA and anti-β2-GP1 antibodies early in pregnancy may predict the occurrence of pregnancy outcome, with superiority over either of the two predictors alone.
Indexed as
Identifiers
35422959PMC8991117W4225896807What OpenQuestion holds
Registered trials
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