ArticleEvidence-based complementary and alternative medicine : eCAM2022
Artemisinin Alleviates Cerebral Ischemia/Reperfusion Injury via Regulation of the Forkhead Transcription Factor O1 Signaling Pathway.
Article in Evidence-based complementary and alternative medicine : eCAM, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Tanshinone IIA Alleviates Traumatic Brain Injury by Reducing Ischemia‒Reperfusion via the miR-124-5p/FoxO1 Axis.Mediators of inflammation · 2024Article
- LITAF inhibits colorectal cancer stemness and metastatic behavior by regulating FOXO1-mediated SIRT1 expression.Clinical & experimental metastasis · 2023Article
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Authors and funding
2 authors.
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Abstract
The effect and mechanism of artemisinin therapy on cerebral ischemia-reperfusion injury (CIRI) was analyzed in this work. 100 healthy male C57BL/6 mice were selected and randomly divided into the sham group (no treatment), CIRI model group (IR), IR + artemisinin posttreatment group (IR + Arte), EX527 + IR group (EX527 + IR), and EX527 + IR + artemisinin posttreatment group (EX527 + IR + Arte), with 20 mice in each group. The cerebral infarct volumes of mice in different groups were measured by the 2,3,5-triphenyltetrazolium chloride (TTC) staining method. The neurological function scores and oxidative stress levels of mice in different groups were measured and compared. In addition, the expressions of silent information regulator 1 (SIRT1), forkhead transcription factor O1 (FOXO1), and p53 protein in brain tissue were detected. The results showed that the contents of reactive oxygen species (ROS) and malondialdehyde (MDA) in the EX527 + IR group and EX527 + IR + Arte group were significantly higher than those in the IR + Arte group (
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