Evidence map›Paper›PMID 35422819›Full record

ArticleFrontiers in immunology2022

Bruton's Tyrosine Kinase Supports Gut Mucosal Immunity and Commensal Microbiome Recognition in Autoimmune Arthritis.

Rachel H Bonami, Christina E Thurman, Sonam Verma, Camille S Westlake, Lindsay E Nyhoff, Bridgette B Barron, Andrea Reboldi, Peggy L Kendall

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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  2. Frontiers in immunology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Rachel H BonamiDepartment of Medicine, Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.
Christina E ThurmanDepartment of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University Medical Center, Nashville, TN, United States.
Sonam VermaDepartment of Medicine, Division of Allergy and Immunology, Washington University School of Medicine, St. Louis, MO, United States.
Camille S WestlakeDepartment of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University Medical Center, Nashville, TN, United States.
Lindsay E NyhoffDepartment of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University Medical Center, Nashville, TN, United States.
Bridgette B BarronDepartment of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University Medical Center, Nashville, TN, United States.
Andrea ReboldiDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Peggy L KendallDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.
Vanderbilt University Medical Center · USUniversity of Massachusetts Chan Medical School · USVanderbilt University · USWashington University in St. Louis · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Building Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3M
Interdisciplinary Training in Rheumatic DiseasesT32AR059039 · NIAMS · VANDERBILT UNIVERSITY · PI Tracy Minan Frech, AMY S MAJOR · 2010 to 2026
$4.3M
Bruton's Tyrosine Kinase and Immune Tolerance in Type 1 DiabetesR01DK084246 · NIDDK · WASHINGTON UNIVERSITY · PI KENDALL, PEGGY L · 2011 to 2019
$3.2M
Diet-derived oxysterols shape intestinal B cell fate by controlling intracellular cholesterol metabolismR01AI155727 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI REBOLDI, ANDREA · 2021 to 2025
$2.3M
B Lymphocytes in Autoimmune DiseaseI01BX002882 · VA · VETERANS HEALTH ADMINISTRATION · PI KENDALL, PEGGY L · 2016 to 2025
–
BLRD VA I01 BX002882NCI NIH HHS P30 CA068485NIAID NIH HHS R01 AI155727NIAMS NIH HHS T32 AR059039NICHD NIH HHS K12 HD043483NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK084246
6 · The paper itself

Abstract

Bruton's tyrosine kinase (

Indexed as

ArthritisAutoimmune DiseasesMicrobiotaAgammaglobulinaemia Tyrosine KinaseAnimalsImmunity, MucosalImmunoglobulin AMiceAgammaglobulinaemia Tyrosine KinaseImmunoglobulin AautoimmunityB cellsBruton’s tyrosine kinaseIgAmicrobiome

Identifiers

PMID35422819
PMCPMC9002138
OpenAlexW4225693858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.