Evidence map›Paper›PMID 35422702›Full record

ArticleFrontiers in pharmacology2022

Pulmonary Inflammatory Response in Lethal COVID-19 Reveals Potential Therapeutic Targets and Drugs in Phases III/IV Clinical Trials.

Andrés López-Cortés, Santiago Guerrero, Esteban Ortiz-Prado, Verónica Yumiceba, Antonella Vera-Guapi, Ángela León Cáceres, Katherine Simbaña-Rivera, Ana María Gómez-Jaramillo, Gabriela Echeverría-Garcés, Jennyfer M García-Cárdenas and 19 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Molecular mechanisms of SARS-CoV-2 entry: implications for biomedical strategies.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  3. Oncolytic virotherapy and tumor microenvironment modulation.Clinical and experimental medicine · 2025
    Review
  4. Article
  5. Peripheral clocks and systemicFrontiers in endocrinology · 2025
    Review
  6. Article
  7. Article
  8. Article
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  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 12 institutions in 6 countries.

Andrés López-CortésPrograma de Investigación en Salud Global, Facultad de Ciencias de la Salud, Universidad Internacional SEK, Quito, Ecuador.
Santiago GuerreroEscuela de Medicina, Facultad de Ciencias Médicas de la Salud y de la Vida, Universidad Internacional del Ecuador, Quito, Ecuador.
Esteban Ortiz-PradoOne Health Research Group, Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador.
Verónica YumicebaInstitut für Humangenetik Lübeck, Universität zu Lübeck, Lübeck, Germany.
Antonella Vera-GuapiIntegrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.
Ángela León CáceresHeidelberg Institute of Global Health, Faculty of Medicine, University of Heidelberg, Heidelberg, Germany.
Katherine Simbaña-RiveraOne Health Research Group, Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador.
Ana María Gómez-JaramilloCentro de Investigación para la Salud en América Latina (CISeAL), Pontificia Universidad Católica del Ecuador, Quito, Ecuador.
Gabriela Echeverría-GarcésLatin American Network for the Implementation and Validation of Clinical Pharmacogenomics Guidelines (RELIVAF-CYTED), Madrid, Spain.
Jennyfer M García-CárdenasEscuela de Medicina, Facultad de Ciencias Médicas de la Salud y de la Vida, Universidad Internacional del Ecuador, Quito, Ecuador.
Patricia Guevara-RamírezLatin American Network for the Implementation and Validation of Clinical Pharmacogenomics Guidelines (RELIVAF-CYTED), Madrid, Spain.
Alejandro Cabrera-AndradeGrupo de Bio-Quimioinformática, Universidad de Las Américas, Quito, Ecuador.
Lourdes Puig San AndrésBIOscience Research Group, Quito, Ecuador.
Doménica Cevallos-RobalinoBIOscience Research Group, Quito, Ecuador.
Jhommara BautistaBIOscience Research Group, Quito, Ecuador.
Isaac Armendáriz-CastilloFacultade de Ciencias, Universidade da Coruña, A Coruña, Spain.
Andy Pérez-VillaLatin American Network for the Implementation and Validation of Clinical Pharmacogenomics Guidelines (RELIVAF-CYTED), Madrid, Spain.
Andrea Abad-SojosBIOscience Research Group, Quito, Ecuador.
María José Ramos-MedinaBIOscience Research Group, Quito, Ecuador.
Ariana León-SosaBIOscience Research Group, Quito, Ecuador.
Estefanía AbarcaBIOscience Research Group, Quito, Ecuador.
Álvaro A Pérez-MezaBiotechnology Engineering Career, Faculty of Life Sciences, Universidad Regional Amazónica Ikiam, Tena, Ecuador.
Karol Nieto-JaramilloBIOscience Research Group, Quito, Ecuador.
Andrea V JácomeFaculty of Medicine, Universidad de Las Américas, Quito, Ecuador.
Andrea MorilloBIOscience Research Group, Quito, Ecuador.
Fernanda Arias-ErazoBIOscience Research Group, Quito, Ecuador.
Luis Fuenmayor-GonzálezBIOscience Research Group, Quito, Ecuador.
Luis Abel QuiñonesLatin American Network for the Implementation and Validation of Clinical Pharmacogenomics Guidelines (RELIVAF-CYTED), Madrid, Spain.
Nikolaos C KyriakidisOne Health Research Group, Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador.
Bioscience Research · USUniversidad de Las Américas · ECUniversidad Internacional del Ecuador · ECHeidelberg University · DEJena University Hospital · DELiga Contra el Cancer · PEPontificia Universidad Católica del Ecuador · ECUniversidade da Coruña · ESUniversidad Internacional SEK · ECUniversidad Regional Amazónica IKIAM · ECUniversity of Chile · CLUniversity of Lübeck · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

clinical trialsdrugslethal COVID-19pulmonary inflammatory responsesingle nucleus RNA sequencing

Identifiers

PMID35422702
PMCPMC9002106
OpenAlexW4221078689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.