ArticleNature and science of sleep2022
Altered Salivary Microbiota in Patients with Obstructive Sleep Apnea Comorbid Hypertension.
Article in Nature and science of sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- The oro- and nasopharyngeal microbiota as a revolutionary perspective on mental disorders and related psychopathology: a systematic review and meta-analysis.Journal of translational medicine · 2025Pooled it
- Microbial dysbiosis in obstructive sleep apnea: a systematic review and meta-analysis.Frontiers in microbiology · 2025Pooled it
- Oral microbiota in obstructive sleep apnea patients: a systematic review.Sleep & breathing = Schlaf & Atmung · 2023Pooled it
- Insufficient sleep and weekend recovery sleep: classification by a metabolomics-based machine learning ensemble.Scientific reports · 2023Trial
- Extending Sleep Improves Sleep and Stress Measures With Limited Microbiome Shift.Journal of sleep research · 2026Article
- Obstructive Sleep Apnea Associated with Periodontitis: Evidence from Mendelian Randomization and Salivary Proteomics.Journal of proteome research · 2026Article
- Impact of Selected Pre-Analytical and Analytical Factors on Untargeted Salivary Metabolomics.International journal of molecular sciences · 2026Article
- Advancements and Challenges in Salivary Metabolomics for Early Detection and Monitoring of Systemic Diseases.MedComm · 2025Review
- VBayesMM: variational Bayesian neural network to prioritize important relationships of high-dimensional microbiome multiomics data.Briefings in bioinformatics · 2025Article
- Association between Serum Uric Acid Levels and Salivary Microbiota in Patients with Obstructive Sleep Apnea.Journal of microbiology and biotechnology · 2025Article
- The Lung Microbiome and Its Impact on Obstructive Sleep Apnea: A Diagnostic Frontier.Diagnostics (Basel, Switzerland) · 2025Review
- Sleep duration associated with altered oral microbiome diversity and composition in the NIH AARP cohort.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Preliminary analysis of salivary microbiota in catathrenia (nocturnal groaning) using machine learning algorithms.Journal of oral microbiology · 2025Article
- Exploratory analysis of potential association between oralFrontiers in cellular and infection microbiology · 2025Article
- The association between the oral microbiome and hypertension: a systematic review.Journal of oral microbiology · 2025Article
- Alterations of the salivary microbiome in obstructive sleep apnea and their association with periodontitis.Frontiers in cellular and infection microbiology · 2025Article
- Insomnia and intestinal microbiota: a narrative review.Sleep & breathing = Schlaf & Atmung · 2024Review
- Microbiota of Saliva: A Non-invasive Diagnostic Tool.Indian journal of microbiology · 2024Review
- Article
- Critical Factors in Sample Collection and Preparation for Clinical Metabolomics of Underexplored Biological Specimens.Metabolites · 2024Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Microorganisms contribute to the pathogenesis of obstructive sleep apnea (OSA)-associated hypertension (HTN), while more studies focus on intestinal microbiome. However, the relationship between oral microbiota and OSA-associated HTN has yet to be elucidated. This study aimed to identify differences in salivary microbiota between patients with OSA comorbid HTN compared with OSA patients, and furthermore evaluate the relationship between oral microbiome changes and increased blood pressure in patients with OSA. Patients and Methods: This study collected salivary samples from 103 participants, including 27 healthy controls, 27 patients with OSA, 23 patients with HTN, and 26 patients with OSA comorbid HTN, to explore alterations of the oral microbiome using 16S rRNA gene V3-V4 high-throughput sequencing. And ultra-high-performance liquid chromatography was used for metabolomic analysis. Results: Alpha- and beta-diversity analyses revealed a substantial difference in community structure and diversity in patients with OSA comorbid HTN compared with patients with OSA or HTN. The relative abundance of the genus Conclusion: This study highlighted noninvasive biomarkers for patients with OSA comorbid HTN. As the first study to find alterations of the salivary microbiome in patients with OSA comorbid HTN, it may provide a theoretical foundation for clinical diagnosis and treatment of this condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.