Evidence map›Paper›PMID 35422631›Full record

ArticleOncoTargets and therapy2022

Genomic Analysis of Tumors from Patients with Glioblastoma with Long-Term Response to Afatinib.

Scott Owen, Scheryll Alken, Jad Alshami, Marie-Christine Guiot, Petr Kavan, David A Reardon, Thierry Muanza, Neil Gibson, Karine Pemberton, Flavio Solca and 2 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in OncoTargets and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 7 countries.

Scott OwenClinical Research Unit, Montreal Neurological Institute and Hospital, McGill University Health Center, Montreal, Canada.
Scheryll AlkenRadiation Oncology Unit, Royal Marsden Hospital, London, UK.
Jad AlshamiClinical Research Unit, Montreal Neurological Institute and Hospital, McGill University Health Center, Montreal, Canada.
Marie-Christine GuiotClinical Research Unit, Montreal Neurological Institute and Hospital, McGill University Health Center, Montreal, Canada.
Petr KavanClinical Research Unit, Montreal Neurological Institute and Hospital, McGill University Health Center, Montreal, Canada.
David A ReardonCenter for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Thierry MuanzaClinical Research Unit, Montreal Neurological Institute and Hospital, McGill University Health Center, Montreal, Canada.
Neil GibsonDrug Metabolism & Pharmacokinetics, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.
Karine PembertonMedical Department, Boehringer Ingelheim Ltd., Bracknell, UK.
Flavio SolcaDepartment of Pharmacology, Boehringer Ingelheim RCV GmbH & Co. KG, Vienna, Austria.
Agnieszka Cseh *Department of Medical Affairs, Boehringer Ingelheim International, Ingelheim am Rhein, Germany.
Frank SaranRadiation Oncology Unit, Royal Marsden Hospital, London, UK.
McGill University · CABoehringer Ingelheim (Germany) · DEMontreal Neurological Institute and Hospital · CAAuckland City Hospital · NZBoehringer Ingelheim (Austria) · ATBoehringer Ingelheim (United Kingdom) · GBCenter for Neuro-Oncology · USSt. James's Hospital · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma is an aggressive form of central nervous system tumor. Recurrence rates following primary therapy are high, and few second-line treatment options provide durable clinical benefit. Aberrations of the epidermal growth factor receptor (

Indexed as

EGFRgenetic aberrationslong-term responsenext-generation sequencing

Identifiers

PMID35422631
PMCPMC9005142
OpenAlexW4226296095

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.