ArticleThe ISME journal2022
Decreased thermal niche breadth as a trade-off of antibiotic resistance.
Article in The ISME journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Eco-Evolutionary Dynamics of Proliferation Heterogeneity: A Phenotype-Structured Model for Tumor Growth and Treatment Response.Bulletin of mathematical biology · 2026Article
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- Oil composition determines microbial preference for carbon source between hydrocarbons and Necromass in water droplets within crude shale oil.ISME communications · 2026Article
- Temperature variability and other climatic attributes linked to genomic features in the lichen-forming fungal genus Umbilicaria.BMC biology · 2025Article
- Effects of Landscape Compositional Heterogeneity and Spatial Autocorrelation on Environmental Niche and Dispersal in Simulated Organisms.Ecology and evolution · 2025Article
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- The tetracycline resistome is shaped by selection for specific resistance mechanisms by each antibiotic generation.Nature communications · 2025Article
- Primed for Discovery.Biochemistry · 2024Review
- From Petri Dishes to Patients to Populations: Scales and Evolutionary Mechanisms Driving Antibiotic Resistance.Annual review of microbiology · 2024Review
- Nonlinear impacts of temperature on antibiotic resistance inEnvironmental science and ecotechnology · 2024Article
- Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs.eLife · 2024Article
- Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs.bioRxiv : the preprint server for biology · 2024Article
- Evolution Under Thermal Stress AffectsbioRxiv : the preprint server for biology · 2024Article
- Protist predation selects for the soil resistome.The ISME journal · 2024Article
- Phage-driven coevolution reveals trade-off between antibiotic and phage resistance inISME communications · 2024Article
- Article
- Thermal adaptation of soil microbial growth traits in response to chronic warming.Applied and environmental microbiology · 2023Article
- Best Practices in Microbial Experimental Evolution.Journal of molecular evolution · 2023Article
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Authors and funding
2 authors.
Funding
Abstract
Evolutionary theory predicts that adaptations, including antibiotic resistance, should come with associated fitness costs; yet, many resistance mutations seemingly contradict this prediction by inducing no growth rate deficit. However, most growth assays comparing sensitive and resistant strains have been performed under a narrow range of environmental conditions, which do not reflect the variety of contexts that a pathogenic bacterium might encounter when causing infection. We hypothesized that reduced niche breadth, defined as diminished growth across a diversity of environments, can be a cost of antibiotic resistance. Specifically, we test whether chloramphenicol-resistant Escherichia coli incur disproportionate growth deficits in novel thermal conditions. Here we show that chloramphenicol-resistant bacteria have greater fitness costs at novel temperatures than their antibiotic-sensitive ancestors. In several cases, we observed no resistance cost in growth rate at the historic temperature but saw diminished growth at warmer and colder temperatures. These results were consistent across various genetic mechanisms of resistance. Thus, we propose that decreased thermal niche breadth is an under-documented fitness cost of antibiotic resistance. Furthermore, these results demonstrate that the cost of antibiotic resistance shifts rapidly as the environment changes; these context-dependent resistance costs should select for the rapid gain and loss of resistance as an evolutionary strategy.
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