Evidence map›Paper›PMID 35422194›Full record

ArticleAutophagy2022

A conserved interplay between FOXO and SNAI/snail in autophagy.

Xiaowei Guo, Xianjue Ma, Lei Xue

Open access · greenAbstract read
In one paragraph

Article in Autophagy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Frontiers in microbiology · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Xiaowei GuoSchool of Medicine, Hunan Normal University, Changsha, Hunan, China.ORCID 0000-0002-8707-7849
Xianjue MaWestlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.
Lei XueInstitute of Intervention Vessel, Shanghai 10th People's Hospital, School of Life Science and Technology, Tongji University, Shanghai, China.ORCID 0000-0001-6947-8414
Tongji University · CNWestlake University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysfunction of macroautophagy/autophagy has been implicated in homeostasis maintenance and contributes to various diseases. Yet the mechanisms that regulate autophagy have not been fully understood. In a recent study, we uncovered a coherent FOXO3-SNAI2 feed-forward regulatory loop in mammals that reinforces autophagy gene induction upon energy stress. Strikingly, a foxo-sna (snail) feed-forward circuit also exists in

Indexed as

AutophagyProteinsAnimalsForkhead Box Protein O3MammalsForkhead Box Protein O3ProteinsAutophagyconservedfeed-forward loopFOXOnuclear exportsnail

Identifiers

PMID35422194
PMCPMC9629153
OpenAlexW4223911103

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.