ArticleCellular and molecular gastroenterology and hepatology2022
Myenteric Neurons Do Not Replicate in Small Intestine Under Normal Physiological Conditions in Adult Mouse.
Article in Cellular and molecular gastroenterology and hepatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Support Cells to Stem Cells: The Promise of Enteric Glia in Treating Gut Neuropathies.Cellular and molecular gastroenterology and hepatology · 2026Article
- Unlocking the Neurogenic Potential of Enteric Glial Cells for Hirschsprung Disease Therapy.Cellular and molecular gastroenterology and hepatology · 2026Article
- The role of the enteric nervous system in the pathogenesis of Clostridioides difficile infection.Nature reviews. Gastroenterology & hepatology · 2025Review
- Article
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- Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy.Nature communications · 2024Article
- Phosphatase and Tensin Homolog Inhibition in Proteolipid Protein 1-Expressing Cells Stimulates Neurogenesis and Gliogenesis in the Postnatal Enteric Nervous System.Biomolecules · 2024Article
- Spatial gene expression profile of Wnt-signaling components in the murine enteric nervous system.Frontiers in immunology · 2024Article
- Dickkopf1 induces enteric neurogenesis and gliogenesis in vitro if apoptosis is evaded.Communications biology · 2023Article
- The enteric nervous system.Physiological reviews · 2023Review
- Who's talking to whom: microbiome-enteric nervous system interactions in early life.American journal of physiology. Gastrointestinal and liver physiology · 2023Review
- BMSCs Promote Differentiation of Enteric Neural Precursor Cells to Maintain Neuronal Homeostasis in Mice With Enteric Nerve Injury.Cellular and molecular gastroenterology and hepatology · 2023Article
- How to Heal the Gut's Brain: Regeneration of the Enteric Nervous System.International journal of molecular sciences · 2022Review
- Reply.Cellular and molecular gastroenterology and hepatology · 2022Article
- Detecting Adult Enteric Neurogenesis in the Context of Adult ENS Homeostasis.Cellular and molecular gastroenterology and hepatology · 2022Article
- Enteric Neurons Get Our Undivided Attention.Cellular and molecular gastroenterology and hepatology · 2022Article
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsThe enteric nervous system (ENS) is the largest part of the peripheral nervous system; moreover, abnormal ENS development and function are associated with multiple human pathologies. Data from several groups suggest that under normal physiological conditions in adult animals, enteric nerve cells do not replicate. A study by Kulkarni et al in 2017 challenged this view and proposed that nearly 70% of enteric neurons in the myenteric ganglia are born in 1 week. The authors of this study suggested that differences in DNA labelling times and DNA denaturation conditions might explain discrepancies with previous reports. Previous studies were carried out using different conditions and labelling techniques in various regions of the gastrointestinal tract; thus, conclusions have remained elusive.
methodsHere, we have eliminated those variables by analyzing the whole small intestine using the reagents and conditions that Kulkarni et al used. To exclude variables related to immunohistochemistry, we carried out parallel experiments with "click chemistry"-based detection of DNA replication.
resultsAlthough proliferation was readily detected in the epithelium, we found no evidence of neuronal replication in the myenteric ganglia.
conclusionsWe conclude that within 1 week under normal physiological conditions, myenteric neurons in the small intestine do not replicate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.