ArticleNeuroImage2022
Harmonizing functional connectivity reduces scanner effects in community detection.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Learning robust and task-invariant functional representation from fMRI through Siamese self-supervised learning.Medical image analysis · 2026Article
- Multi-Site Classification of Autism Spectrum Disorder Using Spatially Constrained ICA on Resting-State fMRI Networks.Brain sciences · 2026Article
- Two axes of white matter development.Nature communications · 2026Article
- Sparse covariate-driven factorization of high-dimensional brain connectivity with application to site effect correction.Biostatistics (Oxford, England) · 2026Article
- Systematic fMRI signal differences across cohorts alter lifespan trajectories of functional brain networks.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Calibration of MRI-based reference intervals to new samples.bioRxiv : the preprint server for biology · 2025Article
- Article
- A multi-site, multi-modal travelling-heads resource for brain MRI harmonisation.Scientific data · 2025Article
- The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program.Schizophrenia (Heidelberg, Germany) · 2025Article
- Analysis of functional connectivity changes from childhood to old age: A study using HCP-D, HCP-YA, and HCP-A datasets.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Individual Variability in the Structural Connectivity Architecture of the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Quantification of brain functional connectivity deviations in individuals: A scoping review of functional MRI studies.NeuroImage. Clinical · 2025Article
- The status of MRI databases across the world focused on psychiatric and neurological disorders.Psychiatry and clinical neurosciences · 2024Review
- Functional connectivity development along the sensorimotor-association axis enhances the cortical hierarchy.Nature communications · 2024Article
- Longitudinal regression of covariance matrix outcomes.Biostatistics (Oxford, England) · 2024Article
- Neural Systems Underlying the Implementation of Working Memory Removal Operations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Methods for and Use of Functional Magnetic Resonance Imaging in Psychiatry.Advances in neurobiology · 2024Review
- Dimensions of early life adversity and their associations with functional brain organisation.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Riemannian frameworks for the harmonization of resting-state functional MRI scans.Medical image analysis · 2024Article
- Effect of data harmonization of multicentric dataset in ASD/TD classification.Brain informatics · 2023Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Community detection on graphs constructed from functional magnetic resonance imaging (fMRI) data has led to important insights into brain functional organization. Large studies of brain community structure often include images acquired on multiple scanners across different studies. Differences in scanner can introduce variability into the downstream results, and these differences are often referred to as scanner effects. Such effects have been previously shown to significantly impact common network metrics. In this study, we identify scanner effects in data-driven community detection results and related network metrics. We assess a commonly employed harmonization method and propose new methodology for harmonizing functional connectivity that leverage existing knowledge about network structure as well as patterns of covariance in the data. Finally, we demonstrate that our new methods reduce scanner effects in community structure and network metrics. Our results highlight scanner effects in studies of brain functional organization and provide additional tools to address these unwanted effects. These findings and methods can be incorporated into future functional connectivity studies, potentially preventing spurious findings and improving reliability of results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.