Evidence map›Paper›PMID 35421431›Full record

ArticlePhytochemistry2022

Polychlorinated cyclopentenes from a marine derived Periconia sp. (strain G1144).

Kristóf B Cank, Robert A Shepherd, Sonja L Knowles, Manuel Rangel-Grimaldo, Huzefa A Raja, Zoie L Bunch, Nadja B Cech, Christopher A Rice, Dennis E Kyle, Joseph O Falkinham and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Phytochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Kristóf B CankDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, 435 Patricia A. Sullivan Science Building, Greensboro, NC, 27402-6170, USA.
Robert A ShepherdDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, 435 Patricia A. Sullivan Science Building, Greensboro, NC, 27402-6170, USA.
Sonja L KnowlesDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, 435 Patricia A. Sullivan Science Building, Greensboro, NC, 27402-6170, USA.
Manuel Rangel-GrimaldoDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, 435 Patricia A. Sullivan Science Building, Greensboro, NC, 27402-6170, USA.
Huzefa A RajaDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, 435 Patricia A. Sullivan Science Building, Greensboro, NC, 27402-6170, USA.
Zoie L BunchDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, 435 Patricia A. Sullivan Science Building, Greensboro, NC, 27402-6170, USA.
Nadja B CechDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, 435 Patricia A. Sullivan Science Building, Greensboro, NC, 27402-6170, USA.
Christopher A RiceDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, 724 Biological Sciences Building, University of Georgia, Athens, GA, 30602-2607, USA; Center for Tropical and Emerging Global Diseases, University of Georgia, 335 Coverdell Center 500 D.W. Brooks Drive, Athens, GA, 30602-7399, USA. Electronic address: christopher.rice@uga.edu.
Dennis E KyleCenter for Tropical and Emerging Global Diseases, University of Georgia, 335 Coverdell Center 500 D.W. Brooks Drive, Athens, GA, 30602-7399, USA. Electronic address: dennis.kyle@uga.edu.
Joseph O FalkinhamDepartment of Biological Sciences, Virginia Tech Center for Drug Discovery, Derring Hall Room 2125, 926 West Campus Drive, Mail Code 0406, Blacksburg, VA, 24061, USA. Electronic address: jofiii@vt.edu.
Joanna E BurdetteDepartment of Pharmaceutical Sciences, University of Illinois at Chicago, 833 South Wood Street, 333 PHARM, MC 781, Chicago, IL, 60612, USA. Electronic address: joannab@uic.edu.
Nicholas H OberliesDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, 435 Patricia A. Sullivan Science Building, Greensboro, NC, 27402-6170, USA. Electronic address: nicholas_oberlies@uncg.edu.
University of North Carolina at Greensboro · USUniversity of Georgia · USUniversity of Illinois Chicago · USVirginia Tech · US

Funding

Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · NCI · OHIO STATE UNIVERSITY · PI Alan Douglas Kinghorn · 2007 to 2026
$27.2M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Predoctoral Training: Innovative Technologies for Natural Products and Integrative Medicine ResearchT32AT008938 · NCCIH · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI Nadja B Cech, Jonathan Rodi Chekan · 2016 to 2026
$1.6M
Co-culturing to Elicit Chemical Diversity in FungiF31AT010558 · NCCIH · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI KNOWLES, SONJA LEE · 2019 to 2020
$65k
NCCIH NIH HHS F31 AT010558NCCIH NIH HHS T32 AT008938NCI NIH HHS P01 CA125066NIEHS NIH HHS P30 ES027792
6 · The paper itself

Abstract

Studies on an organic extract of a marine fungus, Periconia sp. (strain G1144), led to the isolation of three halogenated cyclopentenes along with the known and recently reported rhytidhyester D; a series of spectrometric and spectroscopic techniques were used to elucidate these structures. Interestingly, two of these compounds represent tri-halogenated cyclopentene derivatives, which have been observed only rarely from Nature. The relative and absolute configurations of the compounds were established via mass spectrometry (MS), nuclear magnetic resonance (NMR) spectroscopy, Mosher's esters method, optical rotation and GIAO NMR calculations, including correlation coefficient calculations and the use of both DP4+ and dJ DP4 analyses. Several of the isolated compounds were tested for activity in anti-parasitic, antimicrobial, quorum sensing inhibition, and cytotoxicity assays and were shown to be inactive.

Indexed as

Anti-Infective AgentsAscomycotaAnti-Bacterial AgentsCyclopentanesMagnetic Resonance SpectroscopyMolecular StructureAnti-Bacterial AgentsAnti-Infective AgentsCyclopentanesGIAO NMR calculationsHalogenated cyclopentenesMarine fungiPericonia sp.

Identifiers

PMID35421431
PMCPMC9173697
OpenAlexW4223436562

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.