ArticleAging cell2022
Role of sleep quality in the acceleration of biological aging and its potential for preventive interaction on air pollution insults: Findings from the UK Biobank cohort.
Article in Aging cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Sleep traits and physical activity mediate the causal association between depression and age-related diseases.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- Investigating genetic links between biological aging and adverse pregnancy outcomes.Biogerontology · 2025Pooled it
- Determinants and relationships of climate change, climate change hazards, mental health, and well-being: a systematic review.Frontiers in psychiatry · 2025Pooled it
- The joint and interaction associations of physical activity and sleep with depression: a cohort study.BMC public health · 2026Article
- Obstructive Sleep Apnea and the Risk of Age-Related Macular Degeneration.Journal of vitreoretinal diseases · 2026Article
- Review
- Associations of long-term PMBMC public health · 2026Article
- Associations of accelerated biological ageing with incident dementia, cognitive functions and brain structure: a prospective cohort study based on UK Biobank.Stroke and vascular neurology · 2026Article
- Sleep and circadian rhythms in cardiovascular resilience: mechanisms, implications, and a Roadmap for research and interventions.Nature reviews. Cardiology · 2026Review
- Association of Accelerometer-Measured Light-Intensity Physical Activity with Cardiovascular Diseases: A Large Cohort Study.Health data science · 2026Article
- Repeated device-based measures of daily movement, sedentary behavior, and sleep at 6 months postpartum: the Pregnancy Environment and Lifestyle Study-2 cohort.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Rest-Activity Timing Phenotypes and Mental Health: A Longitudinal Analysis of 24-Hour Accelerometry in Population-Based Cohorts.Health data science · 2026Article
- The association of sleep health with epigenetic aging in early adolescence: exploratory insights from the Health Outcomes and Measures of the Environment study.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Accelerated biological aging and risk of sarcopenia: evidence from 29,000 Chinese adults.Biology of sport · 2026Article
- Molecular markers, mechanisms and metrics of biological aging: a scoping review.Frontiers in aging · 2026Review
- Facial skin aging is a potential osteoporosis-associated marker: evidence from both observational and genetic studies.Journal of bone and mineral metabolism · 2026Article
- Sleep quality and incidence of diabetes in 0.5 million Chinese adults.BMC public health · 2025Article
- The mediation effect of sleep quality on the association between ambient air pollution and type 2 diabetes among UK adults: a population-based cohort study.BMC public health · 2025Article
- Association of body roundness index with risk of all-cause, cardiovascular disease-cause, and cancer-cause mortality: the role of biological age acceleration.Nutrition journal · 2025Article
- The association between dietary iron intake and the incidence of cardiometabolic multimorbidity: the mediating role of biological age.BMC public health · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Sleep has been associated with aging and relevant health outcomes, but the causal relationship remains inconclusive. In this study, we investigated the associations of sleep behaviors with biological ages (BAs) among 363,886 middle and elderly adults from UK Biobank. Sleep index (0 [worst]-6 [best]) of each participant was retrieved from the following six sleep behaviors: snoring, chronotype, daytime sleepiness, sleep duration, insomnia, and difficulties in getting up. Two BAs, the KDM-biological age and PhenoAge, were estimated by corresponding algorithms based on clinical traits, and their residual discrepancies with chronological age were defined as the age accelerations (AAs). We first observed negative associations between the sleep index and the two AAs, and demonstrated that the change of AAs could be the consequence of sleep quality using Mendelian randomization with genetic risk scores of sleep index and BAs. Particularly, a one-unit increase in sleep index was associated with 0.104- and 0.119-year decreases in KDM-biological AA and PhenoAge acceleration, respectively. Air pollution is another key driver of aging. We further observed significant independent and joint effects of sleep and air pollution (PM
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