Evidence map›Paper›PMID 35420890›Full record

ArticleScience (New York, N.Y.)2022

Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging.

Michele Gabriele, Hugo B Brandão, Simon Grosse-Holz, Asmita Jha, Gina M Dailey, Claudia Cattoglio, Tsung-Han S Hsieh, Leonid Mirny, Christoph Zechner, Anders S Hansen

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 319 papers.

0numbers the graph read from it
0cells of the map it votes in
319citing papers in PubMed
41.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

319 citing papers in PubMed, 498 citations in OpenAlex.

  1. Review
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  8. Regulation of immune signal integration and memory by inflammation-induced chromosome conformation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
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  15. Review
  16. Transcription and Three-Dimensional Genome Organization: Cause, Consequence, or Coordination?BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  17. Review
  18. Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  19. Article
  20. Review

259 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Michele Gabriele *Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-5393-9084
Hugo B Brandão *Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0001-5496-0638
Simon Grosse-Holz *Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-0717-5757
Asmita JhaDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Gina M DaileyDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-8988-963X
Claudia CattoglioDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-6100-0491
Tsung-Han S HsiehDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0003-2094-0772
Leonid MirnyDepartment of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-0785-5410
Christoph ZechnerMax Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.ORCID 0000-0003-1300-6076
Anders S HansenDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0001-7540-7858
Broad Institute · USHoward Hughes Medical Institute · USMassachusetts Institute of Technology · USAllen Institute · USCenter for Systems Biology Dresden · DEUniversity of California, Berkeley · US

Funding

Center for 3D Structure and Physics of the GenomeUM1HG011536 · NHGRI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DEKKER, JOB, MIRNY, LEONID A · 2020 to 2024
$11.8M
Polymer models of mitotic and interphase chromosomesR01GM114190 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MIRNY, LEONID A · 2015 to 2023
$2.8M
DYNAMIC BOTTOM-UP DISSECTION OF CHROMATIN LOOPING AND GENE REGULATIONDP2GM140938 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HANSEN, ANDERS SEJR · 2020 to 2020
$2.3M
Super-resolution microscopy for dynamic analysis of focal enhancer amplifications in cancerR33CA257878 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HANSEN, ANDERS SEJR · 2021 to 2023
$1.1M
Molecular mechanisms regulating chromatin looping in time and spaceR00GM130896 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HANSEN, ANDERS SEJR · 2020 to 2022
$747k
NCI NIH HHS R33 CA257878NHGRI NIH HHS UM1 HG011536NIGMS NIH HHS DP2 GM140938NIGMS NIH HHS R00 GM130896NIGMS NIH HHS R01 GM114190
6 · The paper itself

Abstract

Animal genomes are folded into loops and topologically associating domains (TADs) by CTCF and loop-extruding cohesins, but the live dynamics of loop formation and stability remain unknown. Here, we directly visualized chromatin looping at the

Indexed as

ChromatinChromosomal Proteins, Non-HistoneAnimalsBayes TheoremCCCTC-Binding FactorCell Cycle ProteinsCohesinsMiceCCCTC-Binding FactorCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneCohesins

Identifiers

PMID35420890
PMCPMC9069445
OpenAlexW4225320261

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.