Evidence map›Paper›PMID 35420782›Full record

ArticleBioconjugate chemistry2022

Design, Synthesis, and Preliminary Evaluation of [

Jillissa C Taubel, Nicholas R Nelson, Aditya Bansal, Geoffrey L Curran, Lushan Wang, Zengtao Wang, Heather M Berg, Cynthia J Vernon, Hoon-Ki Min, Nicholas B Larson and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Bioconjugate chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Jillissa C TaubelDivision of Nuclear Medicine, Department of Radiology, Mayo Clinic Rochester, Minnesota 55905, United States.
Nicholas R NelsonDivision of Nuclear Medicine, Department of Radiology, Mayo Clinic Rochester, Minnesota 55905, United States.
Aditya BansalDivision of Nuclear Medicine, Department of Radiology, Mayo Clinic Rochester, Minnesota 55905, United States.
Geoffrey L CurranDivision of Nuclear Medicine, Department of Radiology, Mayo Clinic Rochester, Minnesota 55905, United States.
Lushan WangDepartment of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Zengtao WangDepartment of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Heather M BergDivision of Nuclear Medicine, Department of Radiology, Mayo Clinic Rochester, Minnesota 55905, United States.
Cynthia J VernonDivision of Nuclear Medicine, Department of Radiology, Mayo Clinic Rochester, Minnesota 55905, United States.
Hoon-Ki MinDivision of Nuclear Medicine, Department of Radiology, Mayo Clinic Rochester, Minnesota 55905, United States.
Nicholas B LarsonDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota 55905, United States.
Timothy R DeGradoDepartment of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States.
Karunya K KandimallaDepartment of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0001-7786-1915
Val J LoweDivision of Nuclear Medicine, Department of Radiology, Mayo Clinic Rochester, Minnesota 55905, United States.
Mukesh K PandeyDivision of Nuclear Medicine, Department of Radiology, Mayo Clinic Rochester, Minnesota 55905, United States.ORCID 0000-0002-2332-5305
Mayo Clinic · USUniversity of Minnesota · USMayo Clinic in Florida · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Amyloid beta peptides and type-2 diabetes sequelae synergistically inhibit insulin signaling and trafficking at the blood brain barrierR01NS125437 · NINDS · UNIVERSITY OF MINNESOTA · PI KARUNYA KUMAR KANDIMALLA, VAL JOHN LOWE · 2022 to 2026
$2.6M
NINDS NIH HHS R01 NS125437
6 · The paper itself

Abstract

Aberrant insulin signaling has been considered one of the risk factors for the development of Alzheimer's disease (AD) and has drawn considerable attention from the research community to further study its role in AD pathophysiology. Herein, we describe the development of an insulin-based novel positron emission tomography (PET) probe, [

Indexed as

Alzheimer DiseaseGallium RadioisotopesAnimalsHeterocyclic Compounds, 1-RingInsulinMicePositron-Emission TomographyReceptor, Insulin1,4,7-triazacyclononane-N,N',N''-triacetic acidGallium RadioisotopesHeterocyclic Compounds, 1-RingInsulinReceptor, Insulin

Identifiers

PMID35420782
PMCPMC9121347
OpenAlexW4223894206

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.