ArticleMovement disorders : official journal of the Movement Disorder Society2022
Functional Brain Dysconnectivity in Parkinson's Disease: A 5-Year Longitudinal Study.
Article in Movement disorders : official journal of the Movement Disorder Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Altered regional spontaneous brain activity in Parkinson's disease: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Distinct EEG functional network alterations in Parkinson's disease and multiple system atrophy.NeuroImage. Clinical · 2026Article
- What Static Connectivity Misses: Dynamic Alpha-Band Brain Network States in First-Episode Psychosis.Brain topography · 2026Article
- Time-Varying Effective Network of Rehabilitation in Parkinson's Disease With Disease Laterality: A TMS-EEG Study.CNS neuroscience & therapeutics · 2026Article
- Frequency- and Network-Specific Changes in Functional Connectivity Reflect Pathophysiological Mechanisms across Parkinson's Disease Stages.Annals of neurology · 2026Article
- Hippocampal atrophy in untreated de novo Parkinson's disease with obstructive sleep apnea.NPJ Parkinson's disease · 2026Article
- Characteristics and mechanisms of cognitive impairment in Parkinson disease.Nature reviews. Neurology · 2026Review
- Increased blood-brain barrier permeability is associated with dysfunctional α band connectivity in early-stage Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Associations of physical activity, sedentary time, sleep quality, and resting EEG with mild depressive symptoms in college students: a cross-sectional study.BMC public health · 2025Article
- One-month atogepant treatment induces rapid changes in delta-band functional connectivity in migraine: an HD-EEG study.The journal of headache and pain · 2025Article
- Characterizing the heterogeneity of neurodegenerative diseases through EEG normative modeling.NPJ Parkinson's disease · 2025Article
- Changes in sensorimotor network dynamics in resting-state recordings in Parkinson's disease.Brain communications · 2025Article
- Article
- Insular and limbic abnormal functional connectivity in early-stage Parkinson's disease patients with autonomic dysfunction.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Electrophysiological signatures of anxiety in Parkinson's disease.Translational psychiatry · 2024Article
- Network disruption based on multi-modal EEG-MRI in α-synucleinopathies.Frontiers in neurology · 2024Article
- Online cognitive testing in Parkinson's disease: advantages and challenges.Frontiers in neurology · 2024Review
- Access to device-aided therapies in advanced Parkinson's disease: navigating clinician biases, patient preference, and prognostic uncertainty.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Cortical and Subcortical Changes in MEG Activity Reflect Parkinson's Progression over a Period of 7 Years.Brain topography · 2023Article
- Review
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7 authors.
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Abstract
backgroundTracking longitudinal functional brain dysconnectivity in Parkinson's disease (PD) is a key element to decoding the underlying physiopathology and understanding PD progression.
objectivesThe objectives of this follow-up study were to explore, for the first time, the longitudinal changes in the functional brain networks of PD patients over 5 years and to associate them with their cognitive performance and the lateralization of motor symptoms.
methodsWe used a 5-year longitudinal cohort of PD patients (n = 35) who completed motor and non-motor assessments and sequent resting state (RS) high-density electroencephalography (HD-EEG) recordings at three timepoints: baseline (BL), 3 years follow-up (3YFU) and 5 years follow-up (5YFU). We assessed disruptions in frequency-dependent functional networks over the course of the disease and explored their relation to clinical symptomatology.
resultsIn contrast with HC (n = 32), PD patients showed a gradual connectivity impairment in α2 (10-13 Hz) and β (13-30 Hz) frequency bands. The deterioration in the global cognitive assessment was strongly correlated with the disconnected networks. These disconnected networks were also associated with the lateralization of motor symptoms, revealing a dominance of the right hemisphere in terms of impaired connections in the left-affected PD patients in contrast to dominance of the left hemisphere in the right-affected PD patients.
conclusionsTaken together, our findings suggest that with disease progression, dysconnectivity in the brain networks in PD can reflect the deterioration of global cognitive deficits and the lateralization of motor symptoms. RS HD-EEG may be an early biomarker of PD motor and non-motor progression. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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