ArticleThe Journal of clinical endocrinology and metabolism2022
Long-term Weight Change and its Temporal Relation to Later-life Dementia in the Health and Retirement Study.
Article in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Mapping the network structure of dementia and its associated factors among older adults in Singapore: evidence from two national cross-sectional studies.BMC geriatrics · 2026Article
- Association of cystatin C kidney function measures with motoric cognitive risk syndrome: evidence from two cohort studies.The journal of nutrition, health & aging · 2025Article
- The Association of Allergy-Related and Non-Allergy-Related Olfactory Impairment with Cognitive Function in Older Adults: Two Cross- Sectional Studies.Current Alzheimer research · 2024Article
- Article
- The independent and joint association of accelerometer-measured physical activity and sedentary time with dementia: a cohort study in the UK Biobank.The international journal of behavioral nutrition and physical activity · 2023Article
- Association Between Late-Life Weight Change and Dementia: A Population-based Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Predicted lean body mass in relation to cognitive function in the older adults.Frontiers in endocrinology · 2023Article
- Long-term Weight Change and its Temporal Relation to Later-life Dementia in the Health and Retirement Study.The Journal of clinical endocrinology and metabolism · 2022Article
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Authors and funding
9 authors.
Funding
Abstract
contextWeight loss among middle-aged and older adults has been associated with a higher risk of subsequent dementia. However, most studies have limited follow-up durations or suboptimal control for the potential influence of physical frailty (PF).
objectiveOur study aimed to investigate the long-term and temporal relations of weight change to risk of dementia among middle-aged and older adults in the United States.
methodsA total of 5985 participants aged 65 years and older were included from the Health and Retirement Study. History of long-term weight change was calculated using 9 repeated body mass index measurements during 1992-2008. We then followed participants' dementia status from 2008 to 2018. Multivariable Cox proportional hazard models were used.
resultsDuring the study follow-up period (mean = 7.54 years), a total of 682 (11.40%) dementia cases were documented. After adjustment for basic demographic and lifestyle factors, participants with weight loss (median: -0.23 kg/m2 per year) were at a significantly higher risk of dementia (HR = 1.60; 95% CI, 1.33, 1.92), compared with the stable weight group (median: 0.11 kg/m2 per year). This association was attenuated but remained strong and significant after further adjustment for PF (HR = 1.57; 95% CI, 1.30, 1.89). Significant association was observed for weight loss assessed approximately 14 to 18 years preceding dementia diagnosis (HR = 1.30; 95% CI, 1.07, 1.58), and was consistent closer to diagnosis.
conclusionBoth recent and remote weight loss were associated with a higher risk of later-life dementia among middle-aged and older adults independent of PF status.
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