ArticleeLife2022
Hippocampal-hypothalamic circuit controls context-dependent innate defensive responses.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- PAG-dependent defensive strategy selection: From stress-induced rigidity to adaptive flexibility.iScience · 2026Article
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- The anterior hypothalamic area: a hub for convergence of innate and learned threat responding.Brain structure & function · 2026Review
- Anterior hypothalamic nucleus drives distinct defensive responses through cell-type-specific activity.iScience · 2025Article
- Article
- Article
- Article
- Dissociable contributions of the amygdala and ventral hippocampus to stress-induced changes in defensive behavior.Cell reports · 2024Article
- Dopamine-mediated formation of a memory module in the nucleus accumbens for goal-directed navigation.Nature neuroscience · 2024Article
- Age-associated alteration of innate defensive response to a looming stimulus and brain functional connectivity pattern in mice.Scientific reports · 2024Article
- Microglia contribute to mammary tumor-induced neuroinflammation in a female mouse model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Anterior hypothalamic parvalbumin neurons are glutamatergic and promote escape behavior.Current biology : CB · 2023Article
- Advances in neural circuits of innate fear defense behavior.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023Review
- Modulation of social investigation by anterior hypothalamic nucleus rhythmic neural activity.iScience · 2023Article
- Ghrelin system in Alzheimer's disease.Current opinion in neurobiology · 2023Review
- Sparse genetically defined neurons refine the canonical role of periaqueductal gray columnar organization.eLife · 2022Article
- Behavior is movement only but how to interpret it? Problems and pitfalls in translational neuroscience-a 40-year experience.Frontiers in behavioral neuroscience · 2022Review
- Hippocampus-Anterior Hypothalamic Circuit Modulates Stress-Induced Endocrine and Behavioral Response.Frontiers in neural circuits · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Preys use their memory - where they sensed a predatory threat and whether a safe shelter is nearby - to dynamically control their survival instinct to avoid harm and reach safety. However, it remains unknown which brain regions are involved, and how such top-down control of innate behavior is implemented at the circuit level. Here, using adult male mice, we show that the anterior hypothalamic nucleus (AHN) is best positioned to control this task as an exclusive target of the hippocampus (HPC) within the medial hypothalamic defense system. Selective optogenetic stimulation and inhibition of hippocampal inputs to the AHN revealed that the HPC→AHN pathway not only mediates the contextual memory of predator threats but also controls the goal-directed escape by transmitting information about the surrounding environment. These results reveal a new mechanism for experience-dependent, top-down control of innate defensive behaviors.
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Registered trials
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