Evidence map›Paper›PMID 35420475›Full record

ArticlemBio2022

The Leishmania donovani Ortholog of the Glycosylphosphatidylinositol Anchor Biosynthesis Cofactor PBN1 Is Essential for Host Infection.

Adam Roberts, Rupa Nagar, Cordelia Brandt, Katherine Harcourt, Simon Clare, Michael A J Ferguson, Gavin J Wright

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. The endoplasmic reticulum of trypanosomatids: An unrevealed road for chemotherapy.Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Adam RobertsCell Surface Signalling Laboratory, Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom.
Rupa NagarWellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundeegrid.8241.f, Dundee, United Kingdom.
Cordelia BrandtPathogen Support Team, Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom.
Katherine HarcourtPathogen Support Team, Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom.
Simon ClarePathogen Support Team, Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom.
Michael A J FergusonWellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundeegrid.8241.f, Dundee, United Kingdom.
Gavin J WrightCell Surface Signalling Laboratory, Wellcome Sanger Institute, Hinxton, Cambridge, United Kingdom.ORCID 0000-0003-0537-0863
Wellcome Sanger Institute · GBUniversity of Dundee · GB

Funding

Wellcome 101842/Z/13/ZWellcome TrustWellcome Trust 206194
6 · The paper itself

Abstract

Visceral leishmaniasis is a deadly infectious disease caused by Leishmania donovani, a kinetoplastid parasite for which no licensed vaccine is available. To identify potential vaccine candidates, we systematically identified genes encoding putative cell surface and secreted proteins essential for parasite viability and host infection. We identified a protein encoded by

Indexed as

Communicable DiseasesLeishmania donovaniLeishmaniasis VaccinesLeishmaniasis, VisceralAnimalsGlycosylphosphatidylinositolsMammalsMiceVaccines, AttenuatedGlycosylphosphatidylinositolsLeishmaniasis VaccinesVaccines, Attenuatedbioluminescenceenzymeglycophosphatidylinositol biosynthesisleishmaniasismass spectrometryparasitology

Identifiers

PMID35420475
PMCPMC9239262
OpenAlexW4223915637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.