Evidence map›Paper›PMID 35420468›Full record

SynthesismBio2022

Genome-Wide Association Study of Campylobacter

Rebecca M Munday, Rashidul Haque, Ning-Jiun Jan, Genevieve L Wojcik, Chelsea Marie, Dylan Duchen, Alexander J Mentzer, Uma Nayak, Poonum Korpe, Beth D Kirkpatrick and 2 more

Open access · goldAbstract readMeta-Analysis
In one paragraph

Synthesis in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Rebecca M MundayDepartment of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Rashidul HaqueInternational Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Ning-Jiun JanDepartment of Medicine, Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.ORCID 0000-0001-7197-891X
Genevieve L WojcikDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Chelsea MarieDepartment of Medicine, Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.ORCID 0000-0001-8193-2771
Dylan DuchenDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0001-5629-2012
Alexander J MentzerThe Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, UK.
Uma NayakCenter for Public Health Genomics and Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Poonum KorpeDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Beth D KirkpatrickUniversity of Vermont College of Medicine and Vaccine Testing Center, Burlington, Vermont, USA.
William A PetriDepartment of Medicine, Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.ORCID 0000-0002-7268-1218
Priya DuggalDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Johns Hopkins University · USUniversity of Virginia · USCentre for Human Genetics · GBInternational Centre for Diarrhoeal Disease Research · BDUniversity of Vermont · US

Funding

FIELD STUDIES OF IMMUNITY TO AMEBIASIS IN BANGLADESHR01AI043596 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CAROL A GILCHRIST, William A Petri · 1998 to 2026
$7.7M
Role of CREM in Amebic Colitis and Inflammatory Bowel DiseaseR37AI026649 · NIAID · UNIVERSITY OF VIRGINIA · PI William A Petri · 2018 to 2026
$5.0M
Role of Host Protein Kinase C in CryptosporidiosisR01AI148518 · NIAID · UNIVERSITY OF VIRGINIA · PI MARIE, CHELSEA S. · 2020 to 2024
$3.3M
Passive and Acquired Immunity to Cryptosporidiosis in Bangladeshi ChildrenK23AI108790 · NIAID · UNIVERSITY OF VIRGINIA · PI KORPE, POONUM S. · 2014 to 2018
$876k
NIAID NIH HHS K23 AI108790NIAID NIH HHS R01 AI043596NIAID NIH HHS R01 AI148518NIAID NIH HHS R37 AI026649
6 · The paper itself

Abstract

Diarrhea is responsible for the deaths of more than 500,000 children each year, many of whom reside in low-to-middle-income countries (LMICs). Additionally, children with multiple diarrheal infections early in life have increased growth stunting and malnutrition and decreased vaccine efficacy. Two bacteria that contribute to the burden of diarrhea are Campylobacter jejuni and Campylobacter coli, both are endemic in Bangladesh. However, not all children that are exposed to these pathogens, including Campylobacter, will experience diarrhea. We hypothesized that host genetics may influence susceptibility to Campylobacter infections and performed a genome-wide association study in 534 children from two independent birth cohorts in Dhaka, Bangladesh. Infants were monitored for diarrhea for the first 2 years of life and only defined as controls if all diarrheal samples in the first year were negative for Campylobacter jejuni

Indexed as

Campylobacter InfectionsDiarrheaBangladeshCampylobacterFecesGenome-Wide Association StudyHumansInfantInfant, NewbornCampylobacterdiarrheagenetics

Identifiers

PMID35420468
PMCPMC9239263
OpenAlexW4223892734

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.