ReviewCurrent rheumatology reports2022
Update on Uric Acid and the Kidney.
Review in Current rheumatology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Association between gout and the risk of osteoporosis and fractures: a meta-analysis.Zeitschrift fur Rheumatologie · 2024Pooled it
- Influence of xanthine oxidase inhibitors on all-cause mortality in adults: a systematic review and meta-analysis.Cardiology journal · 2024Pooled it
- Pooled it
- Efficacy and safety of tart cherry supplementary citrate mixture on gout patients: a prospective, randomized, controlled study.Arthritis research & therapy · 2023Trial
- Article
- Goose kidney organoids: A new model for studying the metabolic mechanism of goose astrovirus-induced gout.Poultry science · 2026Article
- Uric Acid-Driven Biomarkers and Clinical Outcomes in Metastatic Pancreatic Cancer: A Multicenter Real-World Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Article
- Development and validation of an osteoporosis risk-assessment model for Chinese older adults: a large-scale retrospective study.BMC geriatrics · 2026Article
- Diagnostic Value of Uric Acid/Albumin Ratio and Platelet Indices in Predicting Hypervascularization in the Placenta Accreta Spectrum: A Comparative Retrospective Analysis.Journal of clinical medicine · 2025Article
- The Association and Racial-Ethnic Disparities Between Arthritis and Kidney Stone Disease: A Population Study from 2007 To 2020 US National Health and Nutrition Examination Survey.Journal of racial and ethnic health disparities · 2025Article
- Low Serum Uric Acid as an Independent Predictor of Mortality and Poor Prognosis: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Relationship of the intensity of physical performance and sedentary time with uric acid in patients with type 2 diabetes.Journal of diabetes investigation · 2025Article
- Unraveling the impact of miRNAs on gouty arthritis: diagnostic significance and therapeutic opportunities.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Transcriptomic and Metabolomic Analysis Reveals the Impact of Autophagy Regulation on Purine Content in Mutton.Foods (Basel, Switzerland) · 2025Article
- Risk factors of disease activity and renal damage in patients with systemic lupus erythematosus.International urology and nephrology · 2024Article
- Potassium sodium hydrogen citrate intervention on gut microbiota and clinical features in uric acid stone patients.Applied microbiology and biotechnology · 2024Article
- Self-control study of multi-omics in identification of microenvironment characteristics in urine of uric acid stone.Scientific reports · 2024Article
- Hyperuricemia Increases the Risk of Postoperative Recurrence in Chinese Patients with Chronic Rhinosinusitis.Journal of inflammation research · 2024Article
- Decline in measured glomerular filtration rate is associated with simple renal cyst in Chinese patients with type 2 diabetes.Journal of diabetes investigation · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewIn this review, we report on new findings regarding associations of uric acid with kidney health. We discuss kidney stones, effects of uric acid in chronic kidney disease (CKD), and management of gout in CKD. Recent studies on neuroprotective effects of raising uric acid provide interesting data regarding nephrolithiasis. RECENT
findingsElevated urate levels have been implicated in the progression of chronic kidney disease (CKD), but the results from PERL and CKD-FIX studies did not demonstrate that allopurinol slowed CKD progression. The SURE-PD3 sought to determine if increasing uric acid would slow the progression of Parkinson's disease. Results ultimately did not support this hypothesis, but high urinary uric acid levels caused uric acid stones, not calcium stones. Low urinary pH remains the key to the formation of uric acid stones. Thiazolidinediones improve insulin resistance, which is associated with an increase in urine pH. The most recent research has not supported the hypothesis that lowering serum uric acid levels will slow the progression of CKD or provide neuroprotection in Parkinson's disease. It is still unclear as to why uric acid stone formers have a high net acid excretion. The STOP-GOUT trial demonstrates that there was a lack of significant adverse events with higher urate-lowering dosages of allopurinol and febuxostat, despite patients' kidney function. This may push other studies to administer higher dosages per ACR guidelines. Future studies could then demonstrate decreased progression of CKD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.