ArticleJournal of veterinary internal medicine2022
Effect of diet change in healthy dogs with subclinical cardiac biomarker or echocardiographic abnormalities.
Article in Journal of veterinary internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 18 citations in OpenAlex.
- Multiple Modelling Methods Suggest That Grain-Free Diets Are Not Predictive of New Owner-Reported Cardiac Diagnoses Over Two Years in the Dog Aging Project, Despite Owner Misclassification of Diet.Veterinary medicine and science · 2026Article
- Role of Diet as a Predisposing Factor for Dilated Cardiomyopathy in Dogs: A Narrative Review.Veterinary sciences · 2025Review
- Case report: anaplasma-related myocardial damage in a dog.BMC veterinary research · 2025Article
- Grain-Free Diets for Dogs and Cats: An Updated Review Focusing on Nutritional Effects and Health Considerations.Animals : an open access journal from MDPI · 2025Review
- Different carbohydrate sources in dog foods supported overall health and cardiac function: an 18-mo prospective study in healthy adult dogs.Journal of animal science · 2025Article
- Domestic dogs maintain clinical, nutritional, and hematological health outcomes when fed a commercial plant-based diet for a year.PloS one · 2024Article
- The effect of taurine supplementation on the renin-angiotensin-aldosterone system of dogs with congestive heart failure.Scientific reports · 2023Article
- Comparison of echocardiography, biomarkers and taurine concentrations in cats eating high- or low-pulse diets.Journal of feline medicine and surgery · 2023Article
- Oligosaccharides and diet-related dilated cardiomyopathy in beagles.Frontiers in veterinary science · 2023Article
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- Effect of diet change in healthy dogs with subclinical cardiac biomarker or echocardiographic abnormalities.Journal of veterinary internal medicine · 2022Article
- Echocardiographic and electrocardiographic findings in Irish Wolfhounds eating high-pulse or low-pulse diets.Journal of veterinary internal medicineArticle
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundA recent study showed higher high-sensitivity cardiac troponin I (hs-cTnI) concentrations in healthy dogs eating grain-free (GF) compared to those eating grain-inclusive (GI) diets. HYPOTHESIS/
objectivesHealthy dogs with subclinical cardiac abnormalities eating GF diets at baseline will show improvements in cardiac biomarkers and echocardiographic variables after diet change, whereas healthy dogs eating GI diets at baseline will not improve. ANIMALS: Twenty healthy dogs with subclinical cardiac abnormalities (12 Golden Retrievers, 5 Doberman Pinschers, 3 Miniature Schnauzers).
methodsThis prospective study included dogs with increased hs-cTnI or N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations, or echocardiographic abnormalities. Mixed modeling was used to evaluate echocardiographic, hs-cTnI, and NT-proBNP differences between groups (GF or GI diet at baseline) over time (1 y after diet change).
resultsTen GF and 10 GI dogs were evaluated. There were statistically significant time: group interactions for hs-cTnI (P = .02) and normalized left ventricular internal systolic diameter (LVIDsN; P = .02), with GF dogs showing larger decreases in these variables than GI dogs. Median (range) hs-cTnI (ng/mL) for GF dogs was 0.141 (0.012-0.224) at baseline and 0.092 (0.044-0.137) at 1 y, and for GI dogs was 0.051 (0.016-0.195) at baseline and 0.060 (0.022-0.280) at 1 y. Median LVIDsN for GF dogs was 1.01 (0.70-1.30) at baseline and 0.87 (0.79-1.24) at 1 y, and for GI dogs was 1.05 (0.84-1.21) at baseline and 1.10 (0.85-1.28) at 1 y. CONCLUSIONS AND CLINICAL IMPORTANCE: Decreased hs-cTnI and LVIDsN in GF dogs after diet change supports reversibility of these subclinical myocardial abnormalities.
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