ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022
High-Frequency Ultrasound Boosts Bull and Human Sperm Motility.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Association of sperm DNA fragmentation index with semen quality and ART outcomes: real-world evidence from a retrospective cohort.Basic and clinical andrology · 2026Article
- The 2026 guided acoustic waves roadmap.Journal of physics D: Applied physics · 2026Review
- Thermal Management of SSAW Acoustofluidic Devices: Experimental and Numerical Analysis.Nanomaterials (Basel, Switzerland) · 2025Article
- Integration of Bioengineered Tools in Assisted Reproductive Technologies.Advanced healthcare materials · 2025Review
- Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies.Andrology · 2025Review
- Acoustofluidics: Technology Advances and Applications from 2022 to 2024.Analytical chemistry · 2025Review
- A Review of SAW-Based Micro- and Nanoparticle Manipulation in Microfluidics.Sensors (Basel, Switzerland) · 2025Review
- Surface Acoustic Wave-Enhanced Multi-View Acoustofluidic Rotation Cytometry (MARC) for Pre-Cytopathological Screening.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Assessing the Relationship between proAKAP4 Level and Longevity of Sexed Sperm Quality after Thawing.Veterinary sciences · 2024Article
- Acoustofluidic Actuation of Living Cells.Micromachines · 2024Review
- Making immotile sperm motile using high-frequency ultrasound.Science advances · 2024Article
- Open source board based acoustofluidic transwells for reversible disruption of the blood-brain barrier for therapeutic delivery.Biomaterials research · 2023Article
- Sonomechanobiology: Vibrational stimulation of cells and its therapeutic implications.Biophysics reviews · 2023Review
- Biological Effects and Applications of Bulk and Surface Acoustic Waves on In Vitro Cultured Mammal Cells: New Insights.Biomedicines · 2022Review
- High-Frequency Ultrasound Boosts Bull and Human Sperm Motility.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Sperm motility is a significant predictor of male fertility potential and is directly linked to fertilization success in both natural and some forms of assisted reproduction. Sperm motility can be impaired by both genetic and environmental factors, with asthenozoospermia being a common clinical presentation. Moreover, in the setting of assisted reproductive technology clinics, there is a distinct absence of effective and noninvasive technology to increase sperm motility without detriment to the sperm cells. Here, a new method is presented to boost sperm motility by increasing the intracellular rate of metabolic activity using high frequency ultrasound. An increase of 34% in curvilinear velocity (VCL), 10% in linearity, and 32% in the number of motile sperm cells is shown by rendering immotile sperm motile, after just 20 s exposure. A similar effect with an increase of 15% in VCL treating human sperm with the same setting is also identified. This cell level mechanotherapy approach causes no significant change in cell viability or DNA fragmentation index, and, as such, has the potential to be applied to encourage natural fertilization or less invasive treatment choices such as in vitro fertilization rather than intracytoplasmic injection.
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Registered trials
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