Evidence map›Paper›PMID 35419983›Full record

Observational studyAndrology2022

Erectile and sexual dysfunction in male and female patients with celiac disease: A cross-sectional observational study.

Lorenzo Romano, Raffaele Pellegrino, Carmine Sciorio, Biagio Barone, Antonietta Gerarda Gravina, Antonio Santonastaso, Caterina Mucherino, Silvia Astretto, Luigi Napolitano, Achille Aveta and 7 more

Open access · hybridAbstract readObservational Study
In one paragraph

Observational study in Andrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 4 pooled it
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 57 citations in OpenAlex.

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  3. Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Lorenzo RomanoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", Naples, Italy.
Raffaele PellegrinoHepato-Gastroenterology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Carmine SciorioUrology Unit, ASST "Alessandro Manzoni" Hospital, Lecco, Italy.
Biagio BaroneDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", Naples, Italy.ORCID 0000-0003-4884-132X
Antonietta Gerarda GravinaHepato-Gastroenterology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Antonio SantonastasoHepato-Gastroenterology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Caterina MucherinoGastroenterology Unit, "Sant'Anna and San Sebastiano" Hospital, Caserta, Italy.
Silvia AstrettoGastroenterology Unit, "Sant'Anna and San Sebastiano" Hospital, Caserta, Italy.
Luigi NapolitanoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", Naples, Italy.
Achille AvetaDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", Naples, Italy.
Savio Domenico PandolfoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", Naples, Italy.
Davide LoizzoDivision of Urology, Department of Surgery, VCU Health, Richmond, Virginia, USA.
Francesco Del GiudiceDepartment of Maternal-Infant and Urological Sciences, Policlinico "Umberto I" Hospital, University of Rome "La Sapienza", Rome, Italy.ORCID 0000-0003-3865-5988
Matteo FerroDivision of Urology, European Institute of Oncology IRCSS, Milan, Italy.
Ciro ImbimboDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", Naples, Italy.
Marco RomanoHepato-Gastroenterology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Felice CrocettoDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples "Federico II", Naples, Italy.ORCID 0000-0002-4315-7660
University of Naples Federico II · ITUniversity of Campania "Luigi Vanvitelli" · ITChildren's Hospital of Richmond at VCU · USOspedale Sant'Anna · ITAlessandro Manzoni Hospital · ITEuropean Institute of Oncology · ITPoliclinico Umberto I · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSexual function is often impaired in patients with chronic illnesses. Several patients with chronic gastrointestinal and liver disorders have been shown to suffer from sexual dysfunction, and celiac disease is a highly prevalent gastroenterological disorder.

aimThe aim of this study was to investigate the sexual function incidence and the risk factors for sexual dysfunction in both male and female celiac disease patients.

methodsTwo hundred and eighty-four patients (170 females, 114 males) participated in this cross-sectional observational study in an anonymous manner. Female sexual function was assessed through the Female Sexual Function Index questionnaire. Male sexual function was assessed through the International Index of Erectile Function-5 questionnaire. Clinical-demographic variables were recorded. We investigated differences in the patient-reported outcomes among the different subgroups and whether there were clinical-demographic predictors of sexual dysfunction in our setting.

main outcome measuresPrevalence and assessment of sexual dysfunction in celiac disease patients.

resultsIn the female group, 85 subjects (50%) had a total score compatible with sexual dysfunction: 43 (61.42%) showed low desire, 79 (46.47%) showed arousal disorder, 66 (38.82%) lubrication disorder, and 84 (49.41%) inability of obtaining an orgasm. Also, a large proportion of our female patients, 161 (94.70%), showed sexual discomfort during intercourse. In the male group, 79 patients (62.2%) showed scores compatible with normal erectile function, eight (7.01%) had mild erectile dysfunction, 24 (21.05%) mild to moderate erectile dysfunction, and three (2.63%) presented severe erectile dysfunction. Altered body mass index was significantly associated with sexual dysfunction both in male and female patients. Early age at diagnosis was a significant predictor of sexual dysfunction in male celiac disease patients.

conclusionsA significant proportion of celiac disease patients present sexual dysfunction. Early age at diagnosis and high body mass index seem to predict sexual dysfunction in this clinical setting. Assessment of sexual function should be part of the initial evaluation of celiac disease patients in order to establish a prompt diagnosis and early treatment.

Indexed as

Celiac DiseaseErectile DysfunctionSexual Dysfunction, PhysiologicalCross-Sectional StudiesFemaleHumansMalePenile ErectionSurveys and Questionnairesceliac diseaseFSFIIIEF-5sexual dysfunction

Identifiers

PMID35419983
PMCPMC9324123
OpenAlexW4224029653

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.