Evidence map›Paper›PMID 35419847›Full record

ArticleMycoses2022

Successful control of Candida auris transmission in a German COVID-19 intensive care unit.

Carl Hinrichs, Miriam Wiese-Posselt, Barbara Graf, Christine Geffers, Beate Weikert, Philipp Enghard, Alexander Aldejohann, Annette Schrauder, Andreas Knaust, Kai-Uwe Eckardt and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Mycoses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

  1. Journal of fungi (Basel, Switzerland) · 2026
    Review
  2. Disinfectant tolerance ofMicrobiology spectrum · 2026
    Article
  3. Review
  4. Review
  5. Frontiers in cellular and infection microbiology · 2026
    Review
  6. Article
  7. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. The Gordian Knot ofPathogens (Basel, Switzerland) · 2023
    Review
  13. SevereJournal of intensive medicine · 2023
    Review
  14. Review
  15. Molecular Detection ofJournal of fungi (Basel, Switzerland) · 2023
    Article
  16. Enablers ofCurrent medical mycology · 2023
    Review
  17. Healthcare (Basel, Switzerland) · 2023
    Review
  18. Review
  19. Emergence of highly resistantFrontiers in public health · 2023
    Article
  20. Increasing number of cases and outbreaks caused byEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Carl HinrichsDepartment of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-5038-0350
Miriam Wiese-PosseltInstitute of Hygiene and Environmental Medicine, Charité - Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0001-9300-2563
Barbara GrafLabor Berlin - Charité Vivantes GmbH, Berlin, Germany.
Christine GeffersInstitute of Hygiene and Environmental Medicine, Charité - Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0003-3047-6416
Beate WeikertInstitute of Hygiene and Environmental Medicine, Charité - Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Philipp EnghardDepartment of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-7254-3931
Alexander AldejohannInstitute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.ORCID https://orcid.org/0000-0001-7246-5518
Annette SchrauderLabor Berlin - Charité Vivantes GmbH, Berlin, Germany.
Andreas KnaustLabor Berlin - Charité Vivantes GmbH, Berlin, Germany.
Kai-Uwe EckardtDepartment of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0003-3823-0920
Petra GastmeierInstitute of Hygiene and Environmental Medicine, Charité - Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0001-5520-4287
Oliver KurzaiInstitute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.ORCID https://orcid.org/0000-0002-7277-2646
Humboldt-Universität zu Berlin · DEVivantes Klinikum · DEUniversity of Würzburg · DE

Funding

Robert Koch Institute with funds provided by the German Ministry of Health 1369-240
6 · The paper itself

Abstract

backgroundCandida auris a frequently multidrug-resistant yeast species that poses a global health threat due to its high potential for hospital outbreaks. While C. auris has become endemic in parts of Asia and Africa, transmissions have so far rarely been reported in Western Europe except for Great Britain and Spain. We describe the first documented patient-to-patient transmission of C. auris in Germany in a COVID-19 intensive care unit (ICU) and infection control measures implemented to prevent further spread of the pathogen.

methodsIdentification of C. auris was performed by MALDI-TOF and confirmed by internal transcribed spacer (ITS) sequencing. Antifungal susceptibility testing was carried out. We conducted repeated cross-sectional examinations for the presence of C. auris in the patients of the affected ICU and investigated possible routes of transmission.

resultsThe index patient had been transferred to Germany from a hospital in Northern Africa and was found to be colonised with C. auris. The contact patient developed C. auris sepsis. Infection prevention and control (IPC) measures included strict isolation of the two C. auris patients and regular screening of non-affected patients. No further case occurred during the subsequent weeks. Reusable blades used in video laryngoscope-guided intubation were considered as the most likely vehicle of transmission.

conclusionsIn view of its high risk of transmission, vigilance regarding C. auris colonisation in patients referred from endemic countries is crucial. Strict and immediate IPC measures may have the potential to prevent C. auris outbreaks.

Indexed as

CandidaCOVID-19Antifungal AgentsCandida aurisCross-Sectional StudiesHumansIntensive Care UnitsMicrobial Sensitivity TestsAntifungal Agentsantifungal treatmentCandida aurisCOVID-19infection prevention and control measures

Identifiers

PMID35419847
PMCPMC9115290
OpenAlexW4223969886

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.