Hyperphagia in offsprings of in utero hyperglycemic mothers is associated with increased expression of heparan sulfate proteoglycans in hypothalamus.

Sandeep Subrahmanian, Chandra Gavva, Nandini D Chilkunda

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Article in Molecular and cellular biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 authors at 1 institution in 1 country.

Sandeep SubrahmanianDepartment of Molecular Nutrition, CSIR-Central Food Technological Research Institute, Mysuru, 570 020, India.

Chandra GavvaDepartment of Molecular Nutrition, CSIR-Central Food Technological Research Institute, Mysuru, 570 020, India.

Nandini D ChilkundaDepartment of Molecular Nutrition, CSIR-Central Food Technological Research Institute, Mysuru, 570 020, India. cdnandini@cftri.res.in.ORCID http://orcid.org/0000-0002-4088-8409

Central Food Technological Research Institute · IN

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No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In utero hyperglycemia has consequences on future outcomes in the offsprings. We had earlier shown that in utero hyperglycemia impacts proteoglycans/glycosaminoglycans, one of the key molecules involved in brain development. Hypothalamic HSPGs such as syndecan-1 and syndecan-3 are well known for their involvement in feeding behavior. Therefore, studies were carried out to determine the effect of maternal hyperglycemia on the expression of HSPGs in the hypothalamus of offspring brain. Results revealed increased protein abundance of Syndecan-1 and -3 as well as glypican-1 in postnatal adults from hyperglycemic mothers. This was associated with increased hyperphagia and increased expression of Neuropeptide Y. These results indicate the likely consequences on offsprings exposed to in utero hyperglycemia on its growth.

Indexed as

HyperglycemiaSyndecan-1AdultCinnamatesFemaleHeparan SulfateHumansHyperphagiaHypothalamusMembrane GlycoproteinsMothersThiadiazoles4-phenyl-5-(4-nitrocinnamoyl)-1,3,4-thiadiazolium-2-phenylamineCinnamatesHeparan SulfateMembrane GlycoproteinsSyndecan-1ThiadiazolesFeeding behaviorHeparan sulfate proteoglycansHypothalamusIn utero hyperglycemiaSulfated glycosaminoglycans

Identifiers

PMID35419768

DOI10.1007/s11010-022-04427-y

OpenAlexW4223906875

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.