Evidence map›Paper›PMID 35419618›Full record

ArticleImmunogenetics2022

TLR7 and TLR8 evolution in lagomorphs: different patterns in the different lineages.

Fabiana Neves, João Pedro Marques, Helena Areal, Patrícia Pinto-Pinho, Bruno Colaço, José Melo-Ferreira, Margarida Fardilha, Joana Abrantes, Pedro José Esteves

Abstract read
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In one paragraph

Article in Immunogenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Fabiana NevesCIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Campus de Vairão, Universidade Do Porto, Vairão, Rua Padre Armando Quintas, nr.7, 4485-661, Vairão, Portugal. fabiananeves@cibio.up.pt.ORCID 0000-0002-6593-2269
João Pedro MarquesCIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Campus de Vairão, Universidade Do Porto, Vairão, Rua Padre Armando Quintas, nr.7, 4485-661, Vairão, Portugal.
Helena ArealCIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Campus de Vairão, Universidade Do Porto, Vairão, Rua Padre Armando Quintas, nr.7, 4485-661, Vairão, Portugal.
Patrícia Pinto-PinhoCITAB - Centre for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-Os-Montes and Alto Douro, Vila Real, Portugal.
Bruno ColaçoCITAB - Centre for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-Os-Montes and Alto Douro, Vila Real, Portugal.
José Melo-FerreiraCIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Campus de Vairão, Universidade Do Porto, Vairão, Rua Padre Armando Quintas, nr.7, 4485-661, Vairão, Portugal.
Margarida FardilhaLaboratory of Signal Transduction, Department of Medical Sciences, Institute of Biomedicine - iBiMED, University of Aveiro, Aveiro, Portugal.
Joana AbrantesCIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Campus de Vairão, Universidade Do Porto, Vairão, Rua Padre Armando Quintas, nr.7, 4485-661, Vairão, Portugal.
Pedro José EstevesCIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Campus de Vairão, Universidade Do Porto, Vairão, Rua Padre Armando Quintas, nr.7, 4485-661, Vairão, Portugal.
Universidade do Porto · PTUniversity of Trás-os-Montes and Alto Douro · PTCentre National de la Recherche Scientifique · FRUniversity of Aveiro · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toll-like receptors (TLRs) are one of the most ancient and widely studied innate immune receptors responsible for host defense against invading pathogens. Among the known TLRs, TLR7 and TLR8 sense and recognize single-stranded (ss) RNAs with a dynamic evolutionary history. While TLR8 was lost in birds and duplicated in turtles and crocodiles, TLR7 is duplicated in some birds, but in other tetrapods, there is only one copy. In mammals, with the exception of lagomorphs, TLR7 and TLR8 are highly conserved. Here, we aim to study the evolution of TLR7 and TLR8 in mammals, with a special focus in the order Lagomorpha. By searching public sequence databases, conducting evolutionary analysis, and evaluating gene expression, we were able to confirm that TLR8 is absent in hares but widely expressed in the European rabbit. In contrast, TLR7 is absent in the European rabbit and quite divergent in hares. Our results suggest that, in lagomorphs, more in particular in leporids, TLR7 and TLR8 genes have evolved faster than in any other mammalian group. The long history of interaction with viruses and their location in highly dynamic telomeric regions might explain the pattern observed.

Indexed as

HaresLagomorphaAnimalsRabbitsToll-Like Receptor 7Toll-Like Receptor 8Toll-Like Receptor 7Toll-Like Receptor 8EvolutionLagomorphsTLR7TLR8

Identifiers

PMID35419618
OpenAlexW4223951794

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.