Evidence map›Paper›PMID 35419613›Full record

ArticleInternational journal of oncology2022

Genome‑wide DNA hypomethylation drives a more invasive pancreatic cancer phenotype and has predictive occult distant metastasis and prognosis potential.

Yuhei Endo, Koichi Suzuki, Yasuaki Kimura, Sawako Tamaki, Hidetoshi Aizawa, Iku Abe, Fumiaki Watanabe, Takaharu Kato, Masaaki Saito, Kazushige Futsuhara and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Yuhei EndoDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama 330‑8503, Japan.
Koichi SuzukiDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama 330‑8503, Japan.
Yasuaki KimuraDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama 330‑8503, Japan.
Sawako TamakiDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama 330‑8503, Japan.
Hidetoshi AizawaDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama 330‑8503, Japan.
Iku AbeDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama 330‑8503, Japan.
Fumiaki WatanabeDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama 330‑8503, Japan.
Takaharu KatoDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama 330‑8503, Japan.
Masaaki SaitoDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama 330‑8503, Japan.
Kazushige FutsuharaDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama 330‑8503, Japan.
Hiroshi NodaDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama 330‑8503, Japan.
Fumio KonishiNerima Hikarigaoka Hospital, Tokyo 179‑0072, Japan.
Toshiki RikiyamaDepartment of Surgery, Saitama Medical Center, Jichi Medical University, Saitama 330‑8503, Japan.
Jichi Medical University Saitama Medical Center · JPJichi Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome‑wide DNA hypomethylation is the most common molecular feature in human cancers associated with chromosomal instability (CIN), which is involved in the mechanisms that regulate pancreatic cancer (PC) metastasis. It was investigated whether genome‑wide DNA hypomethylation affects the phenotype in PC via CIN

Indexed as

DNA MethylationPancreatic NeoplasmsChromosomal InstabilityComparative Genomic HybridizationDNAHumansPhenotypePrognosisDNAchromosomal instabilitygenome‑wide DNA hypomethylationoccult distant metastasispancreatic cancerprognosis

Identifiers

PMID35419613
PMCPMC9015190
OpenAlexW4224094628

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.