ArticleLancet regional health. Americas2022
Association of infertility with premature mortality among US women: Prospective cohort study.
Article in Lancet regional health. Americas, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Association between female infertility and stroke mortality: evidence from the PLCO cancer screening trial.Frontiers in endocrinology · 2024Trial
- Genetics of Premature Ovarian Insufficiency: From Molecular Architecture to Precision Medicine.International journal of molecular sciences · 2026Review
- History of infertility, risk of type 2 diabetes and HbADiabetologia · 2026Article
- Reproductive Fitness and the Links to Chronic Disease and Systemic Aging.Physiology (Bethesda, Md.) · 2026Review
- Co-occurrence of endometriosis and uterine fibroids: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Association of LHCGR rs2293275 genotype with ovarian aging in Chinese women: a multicenter population-based study.Reproductive biology and endocrinology : RB&E · 2025Observational
- Multiomic profiling reveals timing of menopause predicts prefrontal cortex aging and cognitive function.Aging cell · 2025Article
- Endometriosis and uterine fibroids and risk of premature mortality: prospective cohort study.BMJ (Clinical research ed.) · 2024Article
- Reproductive genetics and health.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2024Article
- History of Infertility and Midlife Cardiovascular Health in Female Individuals.JAMA network open · 2024Article
- Association between Abortion and All-Cause and Cause-Specific Premature Mortality: A Prospective Cohort Study from the UK Biobank.Health data science · 2024Article
- A prospective cohort study of infertility and cancer incidence.Fertility and sterility · 2023Article
- History of infertility and risk of breast cancer: a prospective cohort study.Breast cancer research and treatment · 2023Article
- Infertility and Risk of Cardiovascular Disease: A Prospective Cohort Study.Journal of the American Heart Association · 2023Article
- History of infertility and long-term weight, body composition, and blood pressure among women in Project Viva.Annals of epidemiology · 2022Article
- Association of infertility with atherosclerotic cardiovascular disease among postmenopausal participants in the Women's Health Initiative.Fertility and sterility · 2022Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
Background: Infertility has been associated with common chronic non-communicable diseases. However, the association of infertility with long-term mortality is unclear. Methods: We followed 101,777 women aged 25-42 years at enrollment between 1989 and 2017. Biennial questionnaires updated participants' infertility status and underlying reasons for infertility throughout their reproductive lifespan. Hazard ratios (HRs) for the associations of infertility with the risk of premature mortality (death before age 70 years) were estimated using Cox proportional hazards models. Findings: During 28 years of follow-up, 2174 women died before age 70 years. Infertility was associated with an HR of 1.26 (95% confidence interval: 1.15 to 1.38) for premature death. This relation was largely driven by deaths from cancer (HR = 1.22, 1.08 to 1.39) and was stronger among women reporting infertility at a younger age (HR = 1.35, 1.19 to 1.52 for age ≤ 25 years; 1.23, 1.10 to 1.38 for age 26-30 years; and 1.10, 0.91 to 1.32 for age > 30 years, compared to no infertility). The premature mortality risk was also higher for women who didn't become pregnant after their first report of infertility (HR = 1.39, 1.25 to 1.54) than among women who reported at least one pregnancy after infertility (HR = 1.12, 1.00 to 1.26). When contributing diagnoses of infertility were evaluated, a greater risk of all-cause mortality was associated with infertility due to ovulatory disorders (HR = 1.28, 1.09 to 1.51) and endometriosis (HR = 1.50, 1.22 to 1.83). Interpretation: Infertility may be associated with a greater risk of premature mortality, particularly cancer mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.