Evidence map›Paper›PMID 35419469›Full record

ArticleMolecular & cellular oncology2021

Turning end-joining upside down in mitosis.

Marta Llorens-Agost, Michael Ensminger, Hang Phuong Le, Wolf-Dietrich Heyer, Markus Löbrich

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular & cellular oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Marta Llorens-AgostRadiation Biology and DNA Repair, Technical University of Darmstadt, Darmstadt, Germany.ORCID https://orcid.org/0000-0003-1169-7643
Michael EnsmingerRadiation Biology and DNA Repair, Technical University of Darmstadt, Darmstadt, Germany.ORCID https://orcid.org/0000-0002-2057-8040
Hang Phuong LeDepartment of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA, USA.
Wolf-Dietrich HeyerDepartment of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA, USA.ORCID https://orcid.org/0000-0002-7774-1953
Markus LöbrichRadiation Biology and DNA Repair, Technical University of Darmstadt, Darmstadt, Germany.ORCID https://orcid.org/0000-0003-3035-4048
Technische Universität Darmstadt · DEUniversity of California, Davis · US

Funding

RECOMBINATIONAL MECHANISMS OF DNA REPAIR IN EUKARYOTESR01GM058015 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI HEYER, WOLF-DIETRICH · 2000 to 2025
$8.8M
Genome instability induced by homologous recombinationR01GM137751 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HEYER, WOLF-DIETRICH · 2020 to 2023
$1.3M
NIGMS NIH HHS R01 GM058015NIGMS NIH HHS R01 GM137751
6 · The paper itself

Abstract

How cells deal with DNA breaks during mitosis is not well understood. While canonical non-homologous end-joining predominates in interphase, it is inhibited in mitosis to avoid telomere fusions. DNA polymerase θ mediated end-joining appears to be repressed in interphase, but promotes break repair in mitosis. The nature and induction time of breaks might determine their fate during mitosis.

Indexed as

c-NHEJDNA repairmitosistetheringTMEJ

Identifiers

PMID35419469
PMCPMC8997260
OpenAlexW3217598231

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.