ArticleFrontiers in cardiovascular medicine2022
Hypertensive Disorders in Pregnancy Are Associated With Congenital Heart Defects in Offspring: A Systematic Review and Meta-Analysis.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Maternal modifiable factors and risk of congenital heart defects: systematic review and causality assessment.BMJ open · 2024Pooled it
- Maternal, Fetal, and Labour Outcomes of Dupilumab Use for Atopic Dermatitis During Pregnancy: A Systematic Review.Journal of cutaneous medicine and surgeryPooled it
- Transcriptomic Analysis ofInternational journal of molecular sciences · 2026Article
- Transcriptomic Analysis ofbioRxiv : the preprint server for biology · 2026Article
- In Utero Diagnosis of Premature Closure of the Foramen Ovale: A Retrospective Case Series Analyzing Neonatal Interventions and Maternal Factors.Pediatric cardiology · 2026Article
- Risk of minor congenital heart defect in infants conceived via assisted reproductive technology: cohort study from the Copenhagen Baby Heart Study.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Article
- Predicting the future for neonates with symptomatic congenital heart disease.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Hypertensive disorders of pregnancy and cancer risk in offspring: A systematic review and meta-analysis.iScience · 2026Article
- Patterns and risk factors of birth defects in Bangladesh: evidence from a neonatal intensive care unit.BMC pregnancy and childbirth · 2026Observational
- Maternal Cardiac Disease and Congenital Heart Disease Risk in Offspring.JAMA network open · 2026Article
- Evidence-based directed acyclic graphs for perinatal pharmacoepidemiologic studies in rheumatology: a structured approach for development and implementation in administrative health data.Frontiers in epidemiology · 2026Article
- Scoping review of biosimilar disease-modifying antirheumatic drugs in pregnancy: evidence gaps and proposed outcome reporting framework.Rheumatology international · 2025Article
- Maternal Immune Activation: Implications for Congenital Heart Defects.Clinical reviews in allergy & immunology · 2025Review
- Folic acid supplementation on congenital heart disease and its dual character.Current research in pharmacology and drug discovery · 2025Review
- The Hidden Relationship between Intestinal Microbiota and Immunological Modifications in Preeclampsia Pathogenesis.International journal of molecular sciences · 2024Review
- Interdependence of placenta and fetal cardiac development.Prenatal diagnosis · 2024Review
- Advanced magnetic resonance imaging detects altered placental development in pregnancies affected by congenital heart disease.Scientific reports · 2024Article
- Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review.Circulation research · 2024Review
- Advanced magnetic resonance imaging detects altered placental development in pregnancies affected by congenital heart disease.Research square · 2024Article
- Longitudinal Behavior of Left-Ventricular Strain in Fetal Growth Restriction.Diagnostics (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Although research indicates an association between hypertensive disorders of pregnancy (HDP) and congenital heart defects (CHDs) in offspring, consistency is still lacking. Therefore, we aimed to synthesize the updated published epidemiologic evidence to estimate the association of maternal HDP with the risk of total CHDs and its phenotypes in offspring. Methods: A systematic search of Web of Science Database, PubMed, and Embase were searched from inception through April 30, 2021 based on a preprepared protocol, and the reference lists were also manually searched. The combined risk estimates were calculated using either the fixed-effect models or random-effect models. Possible heterogeneity moderators were detected by subgroup, sensitivity analyses, and Galbraith plot. Results: Twenty-four studies involving 477,839 CHDs cases among 40,394,699 participants were included in our meta-analysis. Mothers who had HDP exposure were significantly associated with an increased risk of total CHDs compared with non-exposure. When maternal HDP exposure was further subdivided into pre-eclampsia ( Conclusion: Our study suggested that maternal HDP exposure may be associated with an increase in the risk of CHDs in offspring. These findings highlight the need for greater surveillance of pregnant women with HDP exposure to allow early prevention that may be good for reducing the risk of CHDs in offspring. Clinical Trial Registration: [www.ClinicalTrials.gov], identifier [CRD42021268093].
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