Evidence map›Paper›PMID 35419184›Full record

SynthesisJournal of healthcare engineering2021

The Association between Long Noncoding RNA over Expression and Poor Prognosis of Liver Cancer: A Meta-Analysis.

Leiqing Wang, Junzhi Sheng, Haojie Zhang, Baoyuan Xie, Linbiao Xiang, Dong Liu, Xinyuan Zhang, Peihao Zhang, Jinjin Liu

RetractedAbstract readMeta-AnalysisRetracted Publication
In one paragraph

Synthesis in Journal of healthcare engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Leiqing WangThe First School of Clinical Medicine of Lanzhou University, Lanzhou 730000, Gansu, China.ORCID 0000-0002-6312-804X
Junzhi ShengThe First School of Clinical Medicine of Lanzhou University, Lanzhou 730000, Gansu, China.ORCID 0000-0002-9640-6536
Haojie ZhangDepartment of Clinical Medicine, Medical College, Wuhan University of Science and Technology, Wuhan 430065, Hubei, China.ORCID 0000-0002-0753-4131
Baoyuan XieThe Second School of Clinical Medicine of Lanzhou University, Lanzhou 730000, Gansu, China.ORCID 0000-0001-9420-0182
Linbiao XiangThe Second School of Clinical Medicine of Lanzhou University, Lanzhou 730000, Gansu, China.ORCID 0000-0002-1947-587X
Dong LiuThe School of Clinical Medicine of Shi Hezi University, Shi Hezi 832000, Xinjiang, China.ORCID 0000-0001-7562-2945
Xinyuan ZhangThe School of Clinical Medicine of Weifang Medical University, Weifang 261000, Shandong, China.ORCID 0000-0003-4505-4283
Peihao ZhangThe Second School of Clinical Medicine of Lanzhou University, Lanzhou 730000, Gansu, China.ORCID 0000-0002-3845-3668
Jinjin LiuThe First School of Clinical Medicine of Lanzhou University, Lanzhou 730000, Gansu, China.ORCID 0000-0002-5775-3033

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Long noncoding RNA (lncRNA) is considered to be a mediator of carcinogenesis, which may be associated with liver cancer survival. However, the relationship remains inconclusive. Meta-analysis was conducted to analytically review the association between the lncRNA expression level and clinicopathological characteristics and prognostic value of hepatic carcinoma. Materials and Methods: Four databases including Embase, PubMed, Web of Science, and the Cochrane Library were searched to collect studies about the relation between lncRNA overexpression and prognosis of liver cancer, dating from the earliest records of these databases to March 2021. Two researchers independently screened the data and literature to perform a stringent evaluation of the quality of material involved in the study. Meta-analysis was performed by Stata 16.0 software on 42 case-control studies with 6293 samples. Results: The outcomes of meta-analysis are presented as follows: lncRNA overexpression patients had later TNM stage (OR = 0.36, 95% CI (0.31, 0.41), Conclusions: Overexposure of lncRNA is a poor prognostic feature for patients with hepatic carcinoma. The scope of our study was limited because of a lack of relevant research and the poor representativeness and varying quality of the studies involved in the current meta-analysis. Our conclusion still requires higher studies for further validation. This trial is clinically registered with CRD4201920620.

Indexed as

CarcinomaLiver NeoplasmsNeoplasmsRNA, Long NoncodingBiomarkers, TumorHumansPrognosisBiomarkers, TumorRNA, Long Noncoding

Identifiers

PMID35419184
PMCPMC8995546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.