ReviewJournal of clinical and experimental dentistry2022
Is periodontitis associated with obstructive sleep apnea? A systematic review and meta-analysis.
Review in Journal of clinical and experimental dentistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Grading the evidence for the association between periodontal disease and chronic non-communicable diseases: an umbrella review of meta-analyses of observational studies.BMC oral health · 2026Pooled it
- Association Between Obstructive Sleep Apnea and Periodontitis: A Systematic Umbrella Review.Clinical and experimental dental research · 2026Pooled it
- Association of edentulism and obstructive sleep apnea: A systematic review.Journal of prosthodontics : official journal of the American College of Prosthodontists · 2025Pooled it
- Association between sleep-disordered breathing and periodontitis: a meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2023Pooled it
- Cyclic Altitude Training, Mitochondrial Health, and the Oral-Airway Axis: Intermittent Hypoxia Between Adaptation and Disease.Journal of clinical medicine · 2026Review
- Obstructive Sleep Apnea Associated with Periodontitis: Evidence from Mendelian Randomization and Salivary Proteomics.Journal of proteome research · 2026Article
- Exploring the Link Between Inflammatory Gene Variants and Phenotypes of Periodontal Disease and Obstructive Sleep Apnea.Sleep science (Sao Paulo, Brazil) · 2026Article
- Periodontal disease and obstructive sleep apnea: an umbrella review.Frontiers in oral health · 2026Review
- Association between sleep and periodontal disease in adults-an umbrella review.Frontiers in oral health · 2026Review
- Interdisciplinary Perspectives on Dentistry and Sleep Medicine: A Narrative Review of Sleep Apnea and Oral Health.Journal of clinical medicine · 2025Review
- Bidirectional Relationship Between Dental Diseases and Sleep Disturbances in Pediatric Patients.Clinical and experimental dental research · 2025Review
- Snoring Symptoms and Obstructive Sleep Apnea Risk Factors Identified by Doctors of Dental Medicine.Acta stomatologica Croatica · 2025Article
- Association between periodontal disease and systemic diseases: a cross-sectional analysis of current evidence.Military Medical Research · 2024Article
- Association Between `Life's Essential 8' and Periodontitis: A Cross-Sectional Study From the NHANES Database.International dental journal · 2024Article
- Article
- Cryptic Oral Microbiota: What Is Its Role as Obstructive Sleep Apnea-Related Periodontal Pathogens?International journal of environmental research and public health · 2023Article
- Risk of chronic periodontitis in patients with obstructive sleep apnea in Korea: a nationwide retrospective cohort study.Epidemiology and health · 2023Article
- Association between sleep-disordered breathing and periodontal diseases: A systematic review protocol.Frontiers in medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: There are conflicting results on the association between periodontitis and obstructive sleep apnea (OSA). In the present study, we performed a contemporaneous systematic review and meta-analysis to clarify this issue. We also tried to find out whether periodontitis is associated with OSA severity. Material and Methods: We searched the literature published from the inception to 31 December 2021 from the databases of Embase, PubMed, Scopus, and Web of Science, using a combination of suitable keywords, without language restriction. We included observational studies recruiting adults (≥18 years old) that evaluated the association between periodontitis and OSA. Two investigators screened independently the titles and abstracts of the identified articles for potential suitability. We compared the prevalence of periodontitis between OSA-positive and negative individuals using a pooled odds ratio (OR) with a 95% confidence interval (CI). The heterogeneity between the studies was examined by the I2 statistic. Results: Of 265 citations, a total of 10 eligible studies containing 30,994 participants were finally included. Analysis of these studies showed that there was a significant association between periodontitis and OSA (OR=2.17, 95% CI: 1.66-2.83), with no significant heterogeneity between the studies (I2=42.7%, Conclusions: According to the results, periodontitis has a direct association with OSA. Also, periodontitis has been shown to be associated with mild-to-moderate OSA, but not with severe OSA. Further studies are warranted to elucidate the mechanisms of these associations.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.