Evidence map›Paper›PMID 35419059›Full record

ArticleStem cells international2022

Mesenchymal Stem Cells Inhibit the Effects of Dexamethasone in Multiple Myeloma Cells.

Mingyang Deng, Huan Yuan, Hongling Peng, Sufang Liu, Xiang Xiao, Zhihua Wang, Guangsen Zhang, Han Xiao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mingyang DengDepartment of Hematology, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Huan YuanDepartment of Hematology, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Hongling PengDepartment of Hematology, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Sufang LiuDepartment of Hematology, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Xiang XiaoDepartment of Hematology, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Zhihua WangDepartment of Hematology, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Guangsen ZhangDepartment of Hematology, The Second Xiangya Hospital, Central South University, Changsha 410011, China.
Han XiaoDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha 410011, China.ORCID https://orcid.org/0000-0002-9606-7028
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) participate in the occurrence and development of multiple myeloma. This study is aimed at exploring whether the presence of MSCs affects dexamethasone's antitumor effects against multiple myeloma. Multiple myeloma cells (OPM-2 and RPMI8226 cells) were cocultured with MSCs with or without dexamethasone. Cell viability was determined by using cell number count, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and colony formation assay, respectively. Cell cycle distribution and cell apoptosis were evaluated by using flow cytometry. The mRNA and protein expressions of target genes were checked by using qRT-PCR and western blotting, respectively. It was found that cell viability of multiple myeloma cells increased in the presence of MSCs. Besides, the presence of MSCs suppressed cell apoptosis induced by dexamethasone via the regulation of BCL-2 (B cell lymphoma 2). The presence of MSCs also affected the effects of dexamethasone on cell cycle distribution. Similarly, LINC00461 overexpression suppressed the inhibition of cell proliferation, suppressed the induction of cell apoptosis, and affected the effects on cell cycle distribution induced by dexamethasone insult. However, LINC00461 knockdown enhanced the inhibitory effects on cell proliferation and the induction of cell apoptosis induced by dexamethasone. In summary, MSCs inhibited the effects of dexamethasone on multiple myeloma and its regulatory effects were associated with LINC00461.

Identifiers

PMID35419059
PMCPMC9001108
OpenAlexW4226197233

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.