ArticleThe Biochemical journal1986
A systematic series of synthetic chromophoric substrates for aspartic proteinases.
Article in The Biochemical journal, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 176 citations in OpenAlex.
- Enzymatic Characterization of Recombinant Food Vacuole Plasmepsin 4 from the Rodent Malaria Parasite Plasmodium berghei.PloS one · 2015Article
- Ionic derivatives of betulinic acid as novel HIV-1 protease inhibitors.Journal of enzyme inhibition and medicinal chemistry · 2012Article
- Recombinant chymosin used for exact and complete removal of a prochymosin derived fusion tag releasing intact native target protein.Protein science : a publication of the Protein Society · 2009Article
- Purification and characterization of pepsins A1 and A2 from the Antarctic rock cod Trematomus bernacchii.The FEBS journal · 2007Article
- Modification of the substrate specificity of porcine pepsin for the enzymatic production of bovine hide gelatin.Protein science : a publication of the Protein Society · 2000Article
- Modification of luciferase to be a substrate for plant aspartic proteinase.The Biochemical journal · 1999Article
- Identification and characterization of Saccharomyces cerevisiae yapsin 3, a new member of the yapsin family of aspartic proteases encoded by the YPS3 gene.The Biochemical journal · 1999Article
- Aspartic proteinases: Fourier transform infrared spectroscopic studies of a model of the active side.Biophysical journal · 1996Article
- Expression of soluble cloned porcine pepsinogen A in Escherichia coli.The Biochemical journal · 1996Article
- CGP 53437, an orally bioavailable inhibitor of human immunodeficiency virus type 1 protease with potent antiviral activity.Antimicrobial agents and chemotherapy · 1993Article
- Two crystal structures for cathepsin D: the lysosomal targeting signal and active site.The EMBO journal · 1993Article
- Exploration of subsite binding specificity of human cathepsin D through kinetics and rule-based molecular modeling.Protein science : a publication of the Protein Society · 1993Article
- Kinetic parameters for the generation of endothelins-1,-2 and -3 by human cathepsin E.The Biochemical journal · 1992Article
- Direct observation by X-ray analysis of the tetrahedral "intermediate" of aspartic proteinases.Protein science : a publication of the Protein Society · 1992Article
- Article
- Substrate and inhibitor studies with human gastric aspartic proteinases.The Biochemical journal · 1990Article
- The selectivity of statine-based inhibitors against various human aspartic proteinases.The Biochemical journal · 1990Article
- Inhibition of aspartic proteinases by alpha 2-macroglobulin.The Biochemical journal · 1989Article
- Identification of the aspartic proteinases from human erythrocyte membranes and gastric mucosa (slow-moving proteinase) as catalytically equivalent to cathepsin E.The Biochemical journal · 1988Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The hydrolysis of the chromogenic peptide Pro-Thr-Glu-Phe-Phe(4-NO2)-Arg-Leu at the Phe-Phe(4-NO2) bond by nine aspartic proteinases of animal origin and seven enzymes from micro-organisms is described [Phe(4-NO2) is p-nitro-L-phenylalanine]. A further series of six peptides was synthesized in which the residue in the P3 position was systematically varied from hydrophobic to hydrophilic. The Phe-Phe(4-NO2) bond was established as the only peptide bond cleaved, and kinetic constants were obtained for the hydrolysis of these peptide substrates by a representative selection of aspartic proteinases of animal and microbial origin. The value of these water-soluble substrates for structure-function investigations is discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.