Evidence map›Paper›PMID 35419006›Full record

ArticleFrontiers in immunology2022

Variation of Immune Cell Responses in Humans Reveals Sex-Specific Coordinated Signaling Across Cell Types.

Gabriela K Fragiadakis, Zachary B Bjornson-Hooper, Deepthi Madhireddy, Karen Sachs, Han Chen, David R McIlwain, Matthew H Spitzer, Sean C Bendall, Garry P Nolan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Gabriela K FragiadakisDepartment of Microbiology & Immunology, Stanford University, Stanford, CA, United States.
Zachary B Bjornson-HooperDepartment of Microbiology & Immunology, Stanford University, Stanford, CA, United States.
Deepthi MadhireddyDepartment of Microbiology & Immunology, Stanford University, Stanford, CA, United States.
Karen SachsDepartment of Microbiology & Immunology, Stanford University, Stanford, CA, United States.
Han ChenDepartment of Microbiology & Immunology, Stanford University, Stanford, CA, United States.
David R McIlwainDepartment of Microbiology & Immunology, Stanford University, Stanford, CA, United States.
Matthew H SpitzerImmunology Program, Stanford University, Stanford, CA, United States.
Sean C BendallDepartment of Pathology, Stanford University, Stanford, CA, United States.
Garry P NolanDepartment of Microbiology & Immunology, Stanford University, Stanford, CA, United States.
Stanford University · USUniversity of California, San Francisco · US

Funding

Supplement to Enhance Wellness and Resiliency in the Graduate EnvironmentT32GM007276 · NIGMS · STANFORD UNIVERSITY · PI MORRISON, ASHBY J. · 1985 to 2023
$32.9M
RESOURCE-BASED CENTER FOR THE ADVANCEMENT OF PRECISION MEDICINE IN RHEUMATOLOGYP30AR070155 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mary C Nakamura · 2016 to 2026
$8.2M
Balanced signaling cues to guide cell transitions in the blood lineage continuumR01HL120724 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAKRABORTY, ARUP K., NOLAN, GARRY P · 2015 to 2019
$3.7M
Stanford Technology Accelerating Medicines Partnership CenterUH2AR067676 · NIAMS · STANFORD UNIVERSITY · PI ROBINSON, WILLIAM H, UTZ, PAUL JOSEPH · 2014 to 2020
$2.6M
Cancer Systems Biology Scholars ProgramR25CA180993 · NCI · STANFORD UNIVERSITY · PI PLEVRITIS, SYLVIA KATINA · 2014 to 2018
$2.2M
(PQD2)New Biomarkers and Pathways to Enhance Cure in Ovarian CancersR01CA184968 · NCI · STANFORD UNIVERSITY · PI FANTL, WENDY JANE, SIKIC, BRANIMIR I · 2014 to 2017
$2.0M
Quantitatively modeling immune responses to cancerDP5OD023056 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SPITZER, MATTHEW · 2016 to 2020
$1.9M
Mass Cytometry Analysis of Signaling Dysfunction in Duchenne Muscular DystrophyR01NS089533 · NINDS · STANFORD UNIVERSITY · PI BLAU, HELEN M · 2014 to 2017
$1.3M
Multivariate statistical methods, flow cytometry, and network modeling.R01GM109836 · NIGMS · STANFORD UNIVERSITY · PI WONG, WING H. · 2014 to 2017
$1.2M
NCI NIH HHS R01 CA184968NCI NIH HHS R25 CA180993NHLBI NIH HHS R01 HL120724NIAMS NIH HHS P30 AR070155NIAMS NIH HHS UH2 AR067676NIGMS NIH HHS R01 GM109836NIGMS NIH HHS T32 GM007276NIH HHS DP5 OD023056NINDS NIH HHS R01 NS089533
6 · The paper itself

Abstract

Assessing the health and competence of the immune system is central to evaluating vaccination responses, autoimmune conditions, cancer prognosis, and treatment. With an increasing number of studies examining immune dysregulation, there is a growing need for a curated reference of variation in immune parameters in healthy individuals. We used mass cytometry (CyTOF) to profile blood from 86 humans in response to 15

Indexed as

Autoimmune DiseasesSignal TransductionBiomarkersFemaleFlow CytometryHumansImmune SystemMaleBiomarkersCyTOFhumansimmune cellsmass cytometrysignaling

Identifiers

PMID35419006
PMCPMC8995898
OpenAlexW4225983840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.