Evidence map›Paper›PMID 35418983›Full record

ArticleFrontiers in immunology2022

Ficolin-2 Lectin Complement Pathway Mediates Capsule-Specific Innate Immunity Against Invasive Pneumococcal Disease.

Moon H Nahm, Jigui Yu, Juan J Calix, Feroze Ganaie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Probiotic colonization ofInfection and immunity · 2025
    Article
  3. Article
  4. Review
  5. Review
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Moon H NahmDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Jigui YuDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Juan J CalixDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Feroze GanaieDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
University of Alabama at Birmingham · US

Funding

Acquired deficiency of innate immunity (ficolin-2) among elderly adultsR01AG050607 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NAHM, MOON H. · 2015 to 2019
$1.6M
Defining microbial and host determinants of Acinetobacter survival in the urinary tractK08AI148582 · NIAID · WASHINGTON UNIVERSITY · PI CALIX, JUAN JOSE · 2020 to 2024
$714k
NIAID NIH HHS K08 AI148582NIA NIH HHS R01 AG050607
6 · The paper itself

Abstract

Reports conflict regarding which lectin-microbial ligand interactions elicit a protective response from the lectin pathway (LP) of complement. Using fluorescent microscopy, we demonstrate the human lectin ficolin-2 binds to

Indexed as

Complement Pathway, Mannose-Binding LectinLectinsPneumococcal InfectionsFicolinsHumansImmunity, InnateLigandsStreptococcus pneumoniaeFicolinsLectinsLigandscapsuleficolin-2innate immunitylectin complement pathwayStreptococcus pneumoniae

Identifiers

PMID35418983
PMCPMC8996173
OpenAlexW4220936752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.