Evidence map›Paper›PMID 35418974›Full record

ArticleFrontiers in immunology2022

Serum Antibody Binding and Cytotoxicity to Pig Cells in Chinese Subjects: Relevance to Clinical Renal Xenotransplantation.

Tao Li, Hao Feng, Jiaxiang Du, Qiangbing Xia, David K C Cooper, Hongtao Jiang, Songzhe He, Dengke Pan, Gang Chen, Yi Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Tao LiDepartment of Organ Transplantation, The Second Affiliated Hospital of Hainan Medical University, The Transplantation Institute of Hainan Medical University, Haikou, China.
Hao FengInstitute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jiaxiang DuGenetic Engineering Department, Chengdu Clonorgan Biotechnology Co., Ltd., Chengdu, China.
Qiangbing XiaInstitute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
David K C CooperCenter for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA, United States.
Hongtao JiangDepartment of Organ Transplantation, The Second Affiliated Hospital of Hainan Medical University, The Transplantation Institute of Hainan Medical University, Haikou, China.
Songzhe HeDepartment of Organ Transplantation, The Second Affiliated Hospital of Hainan Medical University, The Transplantation Institute of Hainan Medical University, Haikou, China.
Dengke PanClinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China.
Gang ChenInstitute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yi WangDepartment of Organ Transplantation, The Second Affiliated Hospital of Hainan Medical University, The Transplantation Institute of Hainan Medical University, Haikou, China.
Hainan Medical University · CNHuazhong University of Science and Technology · CNHarvard University · USSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital · CNTongji Hospital · CN

Funding

Prolonging life-supported pig kidney and heart graft survival in baboons by suppressing inflammationU19AI090959 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COOPER, DAVID KC · 2010 to 2024
$26.3M
NIAID NIH HHS U19 AI090959
6 · The paper itself

Abstract

Kidney xenotransplantation is expected to contribute to resolving the shortage of kidneys from deceased human donors. Although progress in experimental life-supporting pig renal xenotransplantation has been encouraging, there are still issues to be considered before a clinical trial can be initiated. We attempted to clarify some of these by an

Indexed as

Graft RejectionKidney Failure, ChronicAnimalsAnimals, Genetically ModifiedChinaFemaleHumansImmunoglobulin GImmunoglobulin MKidneyMalePapioSwineTransplantation, HeterologousImmunoglobulin GImmunoglobulin Mbrain-dead organ donorscomplement-mediated cytotoxicityend-stage renal diseasekidneypigxenotransplantation

Identifiers

PMID35418974
PMCPMC8996717
OpenAlexW4220935065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.