Evidence map›Paper›PMID 35418972›Full record

ReviewFrontiers in immunology2022

The Role of B1 Cells in Systemic Lupus Erythematosus.

Zhou She, Cuifang Li, Feifeng Wu, Jueyi Mao, Min Xie, Marady Hun, Amin Sheikh Abdirahman, Senlin Luo, Wuqing Wan, Jidong Tian and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. [Regulatory effects of mesenchymal stem cells on B1 cells and Tfh cells in children with systemic lupus erythematosus].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Zhou SheDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Cuifang LiDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Feifeng WuDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Jueyi MaoDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Min XieDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Marady HunDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Amin Sheikh AbdirahmanDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Senlin LuoDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Wuqing WanDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Jidong TianDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Chuan WenDepartment of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Second Xiangya Hospital of Central South University · CNCentral South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by multisystemic and multi-organ involvement, recurrent relapses and remissions, and the presence of large amounts of autoantibodies in the body as the main clinical features. The mechanisms involved in this disease are complex and remain poorly understood; however, they are generally believed to be related to genetic susceptibility factors, external stimulation of the body's immune dysfunction, and impaired immune regulation. The main immune disorders include the imbalance of T lymphocyte subsets, hyperfunction of B cells, production of large amounts of autoantibodies, and further deposition of immune complexes, which result in tissue damage. Among these, B cells play a major role as antibody-producing cells and have been studied extensively. B1 cells are a group of important innate-like immune cells, which participate in various innate and autoimmune processes. Yet the role of B1 cells in SLE remains unclear. In this review, we focus on the mechanism of B1 cells in SLE to provide new directions to explore the pathogenesis and treatment modalities of SLE.

Indexed as

B-Lymphocyte SubsetsLupus Erythematosus, SystemicAntigen-Antibody ComplexAutoantibodiesB-LymphocytesHumansAntigen-Antibody ComplexAutoantibodiesantibodyB1 cellshumanmicesystemic lupus erythematosus (SLE)

Identifiers

PMID35418972
PMCPMC8995743
OpenAlexW4221010533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.