ArticleFrontiers in neuroscience2022
Altered Cingulum Functioning in Major Depressive Disorder Patient With Suicide Attempts: A Resting-State Functional Magnetic Resonance Imaging Study.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.
- Neural mechanisms of suicide thoughts and behaviors in major depressive disorder: abnormal regional brain activity and its functional connectivity.BMC psychiatry · 2025Pooled it
- Joint and distinct neural structure and function deficits in major depressive disorder with suicidality: a multimodal meta-analysis of MRI studies.Journal of psychiatry & neuroscience : JPNPooled it
- Linking brain structure to stress reactivity: cingulate surface area predicts acute cortisol responses.Psychological medicine · 2026Article
- Enhancing depression diagnosis with augmented brain signal driven decorrelated graph neural networks.Communications medicine · 2026Article
- Modulation of suicide-related neural circuits by transcranial magnetic stimulation and its role in reducing suicide risk.Translational psychiatry · 2025Article
- Regions with Altered Degree Centrality and Their Functional Connectivity in First-Episode Drug-Naïve Major Depressive Disorder: A Resting-State Functional Magnetic Resonance Imaging Study.Alpha psychiatry · 2023Article
- Gender differences in major depressive disorders: A resting state fMRI study.Frontiers in psychiatry · 2022Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Major depressive disorder (MDD) with suicide attempts (SA) poses a significant public health issue. This study aims to identify neurobiological markers for MDD with SA on resting-state brain functional magnetic resonance imaging (rs-fMRI). Methods: Fifty-one unmedicated adult MDD participants, 27 with SA on the Beck Scale for Suicidal Ideation and 24 without SA, underwent rs-fMRI scanning. A group of 30 healthy controls (HC) matched for age, gender, and education-level with MDD were chosen. A whole brain analysis of regional homogeneity (ReHo) was performed on subjects to identify regions where brain activity was associated with SA. Multiple comparison analysis was performed for ReHo. Pearson's correlation analysis was performed between HAMD-SA scores and ReHo. The statistical significance level was set at Results: We examined whether there were significant differences among the three groups in whole brain ReHo during resting state. Subjects with SA showed significant increase of ReHo in the right Cingulum Post in comparison with those without SA. Subjects with SA showed significant decrease of ReHo in the right Cingulate Gyrus/Precuneus in comparison with HC. The mean ReHo from the significant brain region was associated with HAMD-SA (item 3 of the HAMD) scores ( Conclusion: These results indicate that SA is associated with altered resting-state brain activity. The pattern of elevated activity in the cingulum functioning may be related to SA. Identifying cingulum activity associated with SA may help to elucidate its pathogenesis and etiology.
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