Evidence map›Paper›PMID 35418808›Full record

ArticleMolecular imaging2022

The Probe for Renal Organic Cation Secretion (4-Dimethylaminostyryl)-N-Methylpyridinium (ASP+)) Shows Amplified Fluorescence by Binding to Albumin and Is Accumulated

Jacob Schade Engbjerg, Vincenzo Costanzo, Donato Sardella, Luca Bordoni, Steen Jakobsen, Luciano D'Apolito, Jørgen Frøkiær, Francesco Trepiccione, Giovambattista Capasso, Sebastian Frische

Open access · goldAbstract read
In one paragraph

Article in Molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Biomedical optics express · 2023
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Jacob Schade EngbjergDepartment of Biomedicine, University of Aarhus, Aarhus, Denmark.ORCID 0000-0002-5576-8020
Vincenzo CostanzoDepartment of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum-Università di Bologna, Bologna, Italy.ORCID 0000-0002-1995-7991
Donato SardellaDepartment of Biomedicine, University of Aarhus, Aarhus, Denmark.ORCID 0000-0002-7648-1408
Luca BordoniDepartment of Biomedicine, University of Aarhus, Aarhus, Denmark.ORCID 0000-0002-2428-0874
Steen JakobsenDepartment of Nuclear Medicine and PET Center, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-5484-6237
Luciano D'ApolitoBiogem Institute of Molecular Biology and Genetics, Via Camporeale, 83031 Ariano Irpino, Italy.ORCID 0000-0003-4109-3680
Jørgen FrøkiærDepartment of Nuclear Medicine and PET Center, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0002-6206-8065
Francesco TrepiccioneBiogem Institute of Molecular Biology and Genetics, Via Camporeale, 83031 Ariano Irpino, Italy.ORCID 0000-0002-0622-6612
Giovambattista CapassoBiogem Institute of Molecular Biology and Genetics, Via Camporeale, 83031 Ariano Irpino, Italy.ORCID 0000-0003-3469-8614
Sebastian FrischeDepartment of Biomedicine, University of Aarhus, Aarhus, Denmark.ORCID 0000-0002-0270-3602
Aarhus University · DKUniversity of Campania "Luigi Vanvitelli" · ITAarhus University Hospital · DKBiogem · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulation of uremic toxins may lead to the life-threatening condition "uremic syndrome" in patients with advanced chronic kidney disease (CKD) requiring renal replacement therapy. Clinical evaluation of proximal tubular secretion of organic cations (OC), of which some are uremic toxins, is desired, but difficult. The biomedical knowledge on OC secretion and cellular transport partly relies on studies using the fluorescent tracer 4-dimethylaminostyryl)-

Indexed as

AlbuminsKidneyAnimalsCationsFluorescenceHumansMalePyridinium CompoundsRatsRats, Wistar1-methylpyridiniumAlbuminsCationsPyridinium Compounds

Identifiers

PMID35418808
PMCPMC8979605
OpenAlexW4220860290

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.