Evidence map›Paper›PMID 35418748›Full record

ArticleClinical interventions in aging2022

Age-Related Changes in Trabecular Bone Score and Bone Mineral Density in Chinese Men: A Cross-Sectional and Longitudinal Study.

Huan Tang, Wenjuan Di, Hanmei Qi, Juan Liu, Jing Yu, Jinmei Cai, Bing Lai, Guoxian Ding, Peng Cheng

Abstract read
In one paragraph

Article in Clinical interventions in aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Modified criteria for identifying elevated bone mass.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huan TangDepartment of Gerontology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Wenjuan DiDepartment of Gerontology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Hanmei QiDepartment of Gerontology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Juan LiuDepartment of Gerontology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Jing YuDepartment of Gerontology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Jinmei CaiDepartment of Gerontology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Bing LaiDepartment of Gerontology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Guoxian DingDepartment of Gerontology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Peng ChengDepartment of Gerontology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study was designed to explore age-related changes in trabecular bone score (TBS) and bone mineral density (BMD) in Chinese men through cross-sectional and longitudinal studies. Patients and Methods: We included adult men who had at least twice TBS and BMD examinations in our hospital between January 2013 and December 2020. All men were divided into an age subgroup per 10 years, comparing differences in baseline lumbar spine (LS) TBS and BMD at various parts between each age group and analyzing age-related changes in TBS and BMD during follow-up. Results: Baseline data showed that in men aged 36 to 85 years, BMD in the hip region showed a decreasing trend with age (P for trend < 0.01). However, TBS reached a high value around the age of 50, after which it decreased with age (P for trend = 0.03). During a mean follow-up of 3 years, the average annual change rate at TBS was -0.17% in men aged 36 to 85 years, with the fastest decrease rate -1.08% at 66 to 75 years (P < 0.05). The mean annual rate of change in LS BMD in different age subgroups increased with age (P for trend = 0.001). There was no significant decrease in mean annual change in BMD in hip regions. Conclusion: In men aged 36~85 years, the trend of TBS was inconsistent with BMD. Men experience a high value of LS TBS around age 50, later than the commonly believed age of peak BMD, which may reflect developmental differences between bone microstructure and bone minerals. The TBS may be used as a better indicator of changes in bone strength than BMD in adult men at short-term follow-up. The rapid loss of TBS at age 66 to 75 may have implications for the prevention and medication of osteoporosis in men.

Indexed as

Bone DensityCancellous BoneAbsorptiometry, PhotonAgedChinaCross-Sectional StudiesHumansLongitudinal StudiesLumbar VertebraeMaleage-relatedbone lossbone mineral densitymenosteoporosistrabecular bone score

Identifiers

PMID35418748
PMCPMC8999684

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.