ArticleNature2022
Cell transcriptomic atlas of the non-human primate Macaca fascicularis.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 1 of them a synthesis that pooled it.
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127citing papers in PubMed, 1 pooled it
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Who cites it
127 citing papers in PubMed, 1 synthesis or guideline pooled it, 201 citations in OpenAlex.
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67 more citing papers are in PubMed but not listed here.
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Authors and funding
77 authors at 18 institutions in 9 countries.
Lei Han *BGI-Shenzhen, Shenzhen, China.ORCID http://orcid.org/0000-0002-7535-7915
Xiaoyu Wei *BGI-Shenzhen, Shenzhen, China.
Chuanyu Liu *BGI-Shenzhen, Shenzhen, China.ORCID http://orcid.org/0000-0003-2258-0897
Giacomo Volpe *Hematology and Cell Therapy Unit, IRCCS-Istituto Tumori 'Giovanni Paolo II', Bari, Italy.ORCID http://orcid.org/0000-0001-5000-6951
Zhenkun Zhuang *BGI-Shenzhen, Shenzhen, China.
Xuanxuan Zou *BGI-Shenzhen, Shenzhen, China.
Zhifeng Wang *BGI-Shenzhen, Shenzhen, China.
Taotao PanBGI-Shenzhen, Shenzhen, China.
Yue YuanBGI-Shenzhen, Shenzhen, China.
Xiao ZhangState Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
Peng FanState Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
Pengcheng GuoState Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
Yiwei LaiLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.ORCID http://orcid.org/0000-0003-0733-812X
Ying LeiBGI-Shenzhen, Shenzhen, China.
Xingyuan LiuState Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
Feng YuLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Shuncheng ShangguanJoint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, Guangzhou, China.
Guangyao LaiJoint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, Guangzhou, China.
Qiuting DengBGI-Shenzhen, Shenzhen, China.
Ya LiuBGI-Shenzhen, Shenzhen, China.
Liang WuBGI-Shenzhen, Shenzhen, China.
Quan ShiBGI-Shenzhen, Shenzhen, China.
Hao YuBGI-Shenzhen, Shenzhen, China.
Yunting HuangBGI-Shenzhen, Shenzhen, China.
Mengnan ChengBGI-Shenzhen, Shenzhen, China.
Jiangshan XuBGI-Shenzhen, Shenzhen, China.
Yang LiuBGI-Shenzhen, Shenzhen, China.
Mingyue WangBGI-Shenzhen, Shenzhen, China.
Chunqing WangBGI-Shenzhen, Shenzhen, China.
Yuanhang ZhangBGI-Shenzhen, Shenzhen, China.
Duo XieBGI-Shenzhen, Shenzhen, China.ORCID http://orcid.org/0000-0001-7010-3601
Yunzhi YangBGI College and Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
Yeya YuBGI College and Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
Huiwen ZhengBGI College and Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
Yanrong WeiBGI College and Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
Fubaoqian HuangBGI-Shenzhen, Shenzhen, China.
Junjie LeiBGI-Shenzhen, Shenzhen, China.
Waidong HuangBGI-Shenzhen, Shenzhen, China.
Zhiyong ZhuBGI-Shenzhen, Shenzhen, China.
Haorong LuBGI-Shenzhen, Shenzhen, China.
Bo WangBGI-Shenzhen, Shenzhen, China.
Xiaofeng WeiBGI-Shenzhen, Shenzhen, China.
Fengzhen ChenBGI-Shenzhen, Shenzhen, China.
Tao YangBGI-Shenzhen, Shenzhen, China.ORCID http://orcid.org/0000-0003-4211-5183
Wensi DuBGI-Shenzhen, Shenzhen, China.
Jing ChenBGI-Shenzhen, Shenzhen, China.
Shibo XuInstitute for Stem Cells and Neural Regeneration, School of Pharmacy, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.ORCID http://orcid.org/0000-0001-9867-8757
Juan AnLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Carl WardLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.ORCID http://orcid.org/0000-0003-0889-9025
Zongren WangDepartment of Urology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Zhong PeiDepartment of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Chi-Wai WongHuazhen Biosciences, Guangzhou, China.
Xiaolei LiuState Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
Huafeng ZhangDepartment of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China.
Mingyuan LiuState Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
Baoming QinLaboratory of Metabolism and Cell Fate, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.ORCID http://orcid.org/0000-0001-7652-161X
Axel SchambachInstitute of Experimental Hematology, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0003-2743-0070
Joan IsernSpanish National Center for Cardiovascular Research (CNIC), Madrid, Spain.
Liqiang FengState Key Laboratory of Respiratory Diseases, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.ORCID http://orcid.org/0000-0001-6811-2074
Yan LiuInstitute for Stem Cells and Neural Regeneration, School of Pharmacy, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.
Xiangyu GuoJinan University, Guangzhou, China.
Zhen LiuInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Qiang SunInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.
Patrick H MaxwellCambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-0338-2679
Nick BarkerA*STAR Institute of Molecular and Cell Biology, Singapore, Singapore.ORCID http://orcid.org/0000-0003-3566-4475
Pura Muñoz-CánovesDepartment of Experimental and Health Sciences, Pompeu Fabra University (UPF), ICREA and CIBERNED, Barcelona, Spain.ORCID http://orcid.org/0000-0002-7533-9047
Ying GuBGI-Shenzhen, Shenzhen, China.ORCID http://orcid.org/0000-0001-7822-0570
Jan MulderDepartment of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-3717-5018
Mathias UhlenDepartment of Protein Science, Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4858-8056
Tao TanState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.ORCID http://orcid.org/0000-0001-8650-0388
Shiping LiuBGI-Shenzhen, Shenzhen, China.ORCID http://orcid.org/0000-0003-0019-619X
Huanming YangBGI-Shenzhen, Shenzhen, China.
Jian WangBGI-Shenzhen, Shenzhen, China.
Yong HouBGI-Shenzhen, Shenzhen, China. houyong@genomics.cn.ORCID http://orcid.org/0000-0002-0420-0726
Xun XuBGI-Shenzhen, Shenzhen, China. xuxun@genomics.cn.ORCID http://orcid.org/0000-0002-5338-5173
Miguel A EstebanState Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China. miguel@gibh.ac.cn.ORCID http://orcid.org/0000-0002-1426-6809
Longqi LiuBGI-Shenzhen, Shenzhen, China. liulongqi@genomics.cn.ORCID http://orcid.org/0000-0002-5828-5542
BGI Group (China) · CNChinese Academy of Sciences · CNJilin University · CNZhengzhou University · CNGuangzhou Institutes of Biomedicine and Health · CNScience for Life Laboratory · SEAgency for Science, Technology and Research · SGHarvard University · USInstitució Catalana de Recerca i Estudis Avançats · ESIstituto Tumori Bari · ITJinan University · CNKunming University of Science and Technology · CNNanjing Medical University · CNSpanish National Centre for Cardiovascular Research · ESSun Yat-sen University · CNTianjin Medical University General Hospital · CNUniversity of Cambridge · GBUniversity of Science and Technology of China · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell-cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.
Indexed as
Macaca fascicularisTranscriptomeAnimalsCell CommunicationReceptors, VirusWnt Signaling PathwayReceptors, Virus
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