ArticleNature2022
Mapping human haematopoietic stem cells from haemogenic endothelium to birth.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers.
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162citing papers in PubMed
27.9field-weighted citation impact, top 1% of its field
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Who cites it
162 citing papers in PubMed, 245 citations in OpenAlex.
- Article
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- Harnessing macrophage signaling pathways and scalable engineering for next-generation immunotherapies.Signal transduction and targeted therapy · 2026Review
- RUNX1+23 enhancer marks erythro-megakaryocyte lineages in early waves of hematopoiesis in human ESC differentiation.Blood advances · 2026Article
- Transcriptional landscape of direct reprogramming toward the hematopoietic lineage.bioRxiv : the preprint server for biology · 2026Article
- SPINK2 in hematopoiesis and cancer: Biology and clinical implications.Cell death discovery · 2026Review
- Synthetic developmental engineering of human liver organogenesis.Development (Cambridge, England) · 2026Review
- Macrophages in embryonic development.Nature reviews. Immunology · 2026Review
- The Gut-Bone Marrow Axis: Deciphering the Mechanistic Impact of Microbial Metabolites on Hematopoietic Homeostasis and Disorders.Microorganisms · 2026Review
- AbioRxiv : the preprint server for biology · 2026Article
- Flow-Induced Yap/Taz Signaling Balances Endothelial and Hematopoietic Stem Cell Fates.bioRxiv : the preprint server for biology · 2026Article
- TCF3::HLF orchestrates an enhancer-promoter network with activation of MEF2C to promote immature HSC gene expression in leukemia.Science advances · 2026Article
- Artificial Intelligence Virtual Organoids (AIVOs).Bioactive materials · 2026Review
- A transgene-free, human peri-gastrulation embryo model presents trilaminar embryonic disc-, amnion- and yolk sac-like structures.Nature cell biology · 2026Article
- Fetal-restricted hematopoietic progenitors arise from hemogenic endothelium in vitelline and umbilical arteries.Nature cardiovascular research · 2026Article
- Efficient Generation of Functional TCRαβbioRxiv : the preprint server for biology · 2026Article
- Vesicles for cell crosstalk in bone: composition, function and application.Science China. Life sciences · 2026Review
- SPINK2 silencing suppresses leukemic proliferation and restores myeloid commitment via MECOM downregulation in acute myeloid leukaemia.Cell death discovery · 2026Article
102 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 5 institutions in 4 countries.
Vincenzo Calvanese *Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA. v.calvanese@ucl.ac.uk.ORCID http://orcid.org/0000-0002-7937-1511
Sandra Capellera-Garcia *Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA.
Feiyang Ma *Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6260-0787
Iman FaresDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA.
Simone LiebscherInstitute of Biomedical Engineering, Department for Medical Technologies and Regenerative Medicine, Eberhard Karls University, Tübingen, Germany.
Elizabeth S NgMurdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.
Sophia EkstrandDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA.
Júlia Aguadé-GorgorióDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-5600-4279
Anastasia VavilinaDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA.
Diane LefaudeuxSignaling Systems Laboratory, Department of Microbiology Immunology and Molecular Genetics (MIMG), University of California Los Angeles, Los Angeles, CA, USA.
Brian NadelDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-9583-8169
Jacky Y LiMurdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.
Yanling WangDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA.
Lydia K LeeDepartment of Obstetrics and Gynecology, University of California Los Angeles, Los Angeles, CA, USA.
Reza ArdehaliEli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-1318-4016
M Luisa Iruela-ArispeCell and Developmental Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-3050-4168
Matteo PellegriniDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA.
Ed G StanleyMurdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.
Andrew G ElefantyMurdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0001-6448-8314
Katja Schenke-LaylandInstitute of Biomedical Engineering, Department for Medical Technologies and Regenerative Medicine, Eberhard Karls University, Tübingen, Germany.ORCID http://orcid.org/0000-0001-8066-5157
Hanna K A MikkolaDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA. hmikkola@mcdb.ucla.edu.ORCID http://orcid.org/0000-0002-3400-1496
University of California, Los Angeles · USRoyal Children's Hospital · AUNorthwestern University · USQB3 · USUniversity of Tübingen · DE
Funding
Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5MVirology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KITCHEN, SCOTT G · 1991 to 2018
$39.9MVascular Biology Training GrantT32HL069766 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE · 2002 to 2022
$7.4MVascular Growth and RegenerationR35HL140014 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRUELA-ARISPE, M. LUISA · 2018 to 2024
$6.6MTraining in Developmental HematologyT32HL086345 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KOHN, DONALD B · 2007 to 2022
$3.8MDefining the Self-Renewal Program in Human Hematopoietic Stem CellsR01DK100959 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKKOLA, HANNA KATRI ANNIKKI · 2014 to 2022
$2.9MREGULATION OF HUMAN HEMATOPOIETIC STEM CELL FATE VIA MLLT3 ISOFORMSR01DK121557 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Hanna Katri Annikki Mikkola · 2019 to 2026
$2.3MGeneration of mature human embryonic stem cell-derived left ventricular cardiomyocytes for transplantation in a large animal modelR01HL148714 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARDEHALI, REZA · 2019 to 2022
$2.2MMapping human hematopoietic stem cell developmentR01DK125097 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKKOLA, HANNA KATRI ANNIKKI · 2021 to 2023
$917kNCI NIH HHS P30 CA016042NHLBI NIH HHS R01 HL148714NHLBI NIH HHS R35 HL140014NHLBI NIH HHS T32 HL069766NHLBI NIH HHS T32 HL086345NIAID NIH HHS P30 AI028697NIDDK NIH HHS R01 DK100959NIDDK NIH HHS R01 DK121557NIDDK NIH HHS R01 DK125097
Abstract
The ontogeny of human haematopoietic stem cells (HSCs) is poorly defined owing to the inability to identify HSCs as they emerge and mature at different haematopoietic sites
Indexed as
Endothelial CellsHematopoietic Stem CellsCell DifferentiationEndotheliumFemaleHematopoiesisHumansMesonephrosPregnancy
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