Evidence map›Paper›PMID 35418684›Full record

ArticleNature2022

Somatic mutation rates scale with lifespan across mammals.

Alex Cagan, Adrian Baez-Ortega, Natalia Brzozowska, Federico Abascal, Tim H H Coorens, Mathijs A Sanders, Andrew R J Lawson, Luke M R Harvey, Shriram Bhosle, David Jones and 29 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 265 papers.

0numbers the graph read from it
0cells of the map it votes in
265citing papers in PubMed
39.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

265 citing papers in PubMed, 441 citations in OpenAlex.

  1. Article
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  4. Energy constraint on human health.Trends in endocrinology and metabolism: TEM · 2026
    Review
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  7. The Hallmarks of Aging: From Molecular Mechanisms to Clinical Translation.International journal of molecular sciences · 2026
    Review
  8. Article
  9. Evolutionary genetics of ageing.Nature reviews. Genetics · 2026
    Review
  10. Article
  11. Somatic mutations and genome mosaicism in aging and disease.Experimental & molecular medicine · 2026
    Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Evolution of the highest fidelity DNA replication systems.bioRxiv : the preprint server for biology · 2026
    Article

205 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

39 authors at 7 institutions in 4 countries.

Alex Cagan *Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK. ac36@sanger.ac.uk.ORCID http://orcid.org/0000-0002-7857-4771
Adrian Baez-Ortega *Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.
Natalia BrzozowskaCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.
Federico AbascalCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-6201-1587
Tim H H CoorensCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-5826-3554
Mathijs A SandersCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.
Andrew R J LawsonCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0003-3592-1005
Luke M R HarveyCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.
Shriram BhosleCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-7638-2899
David JonesCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-0407-0386
Raul E AlcantaraCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.
Timothy M ButlerCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0001-5803-1035
Yvette HooksCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.
Kirsty RobertsCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.
Elizabeth AndersonCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.
Sharna LunnCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.
Edmund FlachWildlife Health Services, Zoological Society of London, London, UK.
Simon SpiroWildlife Health Services, Zoological Society of London, London, UK.ORCID http://orcid.org/0000-0002-9621-2192
Inez JanuszczakWildlife Health Services, Zoological Society of London, London, UK.
Ethan WrigglesworthWildlife Health Services, Zoological Society of London, London, UK.
Hannah JenkinsWildlife Health Services, Zoological Society of London, London, UK.
Tilly DallasWildlife Health Services, Zoological Society of London, London, UK.
Nic MastersWildlife Health Services, Zoological Society of London, London, UK.
Matthew W PerkinsInstitute of Zoology, Zoological Society of London, London, UK.
Robert DeavilleInstitute of Zoology, Zoological Society of London, London, UK.
Megan DruceDivision of Experimental Hematology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ruzhica BogeskaDivision of Experimental Hematology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Michael D MilsomDivision of Experimental Hematology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-3567-254X
Björn NeumannWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Frank GormanDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Fernando Constantino-CasasDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Laura PeacheyDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Diana BochynskaDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-0219-8818
Ewan St John SmithDepartment of Pharmacology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-2699-1979
Moritz GerstungEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.ORCID http://orcid.org/0000-0001-6709-963X
Peter J CampbellCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-3921-0510
Elizabeth P MurchisonDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-7462-8907
Michael R StrattonCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0001-6035-153X
Iñigo MartincorenaCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK. im3@sanger.ac.uk.ORCID http://orcid.org/0000-0003-1122-4416
Wellcome Sanger Institute · GBZoological Society of London · GBUniversity of Cambridge · GBGerman Cancer Research Center · DEEuropean Bioinformatics Institute · GBUniversity of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca · ROWellcome/MRC Cambridge Stem Cell Institute · GB

Funding

Cancer Research UK 21777Wellcome TrustWellcome Trust 206194
6 · The paper itself

Abstract

The rates and patterns of somatic mutation in normal tissues are largely unknown outside of humans

Indexed as

LongevityMutation RateAnimalsHumansMammalsMutagenesisMutation

Identifiers

PMID35418684
PMCPMC9021023
OpenAlexW4225246272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.